Hiponatremia intermitente recurrente : un nuevo modelo experimental. Estudio de su efecto sobre el balance hidrosalino y el sistema nervioso central
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2023
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21/04/2023
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Universidad Complutense de Madrid
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Abstract
La hiponatremia es el trastorno hidroelectrolítico más frecuentemente encontrado en la práctica clínica humana. Incluso en formas leves, se asocia con peor pronóstico y mayor mortalidad global, a pesar de lo cual sigue existiendo una tendencia a minimizar la importancia de pequeñas alteraciones en la natremia, que tradicionalmente no se han asociado con consecuencias negativas, pese a la creciente evidencia en contra. En este sentido, no se ha estudiado hasta la fecha si presentar una hiponatremia intermitente, pero recurrente en el tiempo, es relevante. Existen situaciones en clínica humana donde esta condición podría ocurrir y pasar desapercibida, como en la cirrosis o enl a insuficiencia cardiaca...
Hyponatremia is the most common electrolyte disturbance in clinical care. Even mild presentations are associated with poor prognosis and an increased mortality, in spite of which there is a trend to minimize the importance of small variations in natremia, that have historically been dismissed as not having negative consequences despite growing evidence against it. In this regard, it has not been studied to date whether an intermittent but recurrent hyponatremia is relevant. There are clinical scenarios where this condition could occur and be overlooked, such as cirrhosis or heart failure...
Hyponatremia is the most common electrolyte disturbance in clinical care. Even mild presentations are associated with poor prognosis and an increased mortality, in spite of which there is a trend to minimize the importance of small variations in natremia, that have historically been dismissed as not having negative consequences despite growing evidence against it. In this regard, it has not been studied to date whether an intermittent but recurrent hyponatremia is relevant. There are clinical scenarios where this condition could occur and be overlooked, such as cirrhosis or heart failure...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 21-04-2023