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Functional Integrin Regulation Through Interactions with Tetraspanin CD9

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dc.book.titleThe Integrin Interactome: Methods and Protocols
dc.contributor.authorTorres Gómez, Álvaro
dc.contributor.authorCardeñes, Beatriz
dc.contributor.authorDíez Sainz, Ester
dc.contributor.authorLafuente Duarte, María Esther
dc.contributor.authorCabañas Gutiérrez, Carlos
dc.contributor.editorMiguel Vicente-Manzanares
dc.date.accessioned2025-01-27T07:40:54Z
dc.date.available2025-01-27T07:40:54Z
dc.date.issued2020-11-20
dc.description.abstractIntegrins are adhesion receptors that mediate many intercellular and cell-extracellular matrix interactions with relevance in physiology and pathology. Unlike other cellular receptors, integrins critically require activation for ligand binding. Through interaction in cis with other molecules and the formation of tetraspanin-enriched membrane microdomains (TEMs), the tetraspanin CD9 regulates integrin activity and avidity. Here we present three techniques used to study CD9-integrin interactions and integrin activation.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio Español de Economı́a y Competitividad (España)
dc.description.statuspub
dc.identifier.citationTorres-Gómez, Á., Cardeñes, B., Díez-Sainz, E., Lafuente, E. M., & Cabañas, C. (2021). Functional Integrin Regulation Through Interactions with Tetraspanin CD9. Methods in molecular biology (Clifton, N.J.), 2217, 47–56. https://doi.org/10.1007/978-1-0716-0962-0_5
dc.identifier.doi10.1007/978-1-0716-0962-0_5
dc.identifier.isbn9781071609613
dc.identifier.isbn9781071609620
dc.identifier.issn1064-3745
dc.identifier.issn1940-6029
dc.identifier.officialurlhttps://link.springer.com/protocol/10.1007/978-1-0716-0962-0_5
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33215376/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/116124
dc.language.isoeng
dc.page.final56
dc.page.initial47
dc.publication.placeUnited States
dc.publisherSpringer Nature Link
dc.relation.ispartofseriesMethods in molecular biology
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PLAN ESTATAL DE INVESTIGACION CIENTIFICA Y TÉCNICA Y DE INNOVACIÓN 2013-2016/SAF2016-77096-R
dc.rights.accessRightsmetadata only access
dc.subject.cdu612.017
dc.subject.keywordCD9
dc.subject.keywordCoimmunoprecipitation
dc.subject.keywordIntegrin
dc.subject.keywordProximity-ligation assay (PLA)
dc.subject.keywordPull-down assay
dc.subject.keywordTetraspanin
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmInmunología
dc.subject.unesco2412 Inmunología
dc.titleFunctional Integrin Regulation Through Interactions with Tetraspanin CD9
dc.typebook part
dc.type.hasVersionVoR
dc.volume.number2217
dspace.entity.typePublication
relation.isAuthorOfPublicationb4a7a1f5-b9a8-4663-b1bc-96d5d0c50fa1
relation.isAuthorOfPublicationf6c03a66-fd6a-4e17-87a1-9d03052cadb9
relation.isAuthorOfPublication59796ff5-7a9a-4809-af4a-af5ec77ba070
relation.isAuthorOfPublication.latestForDiscoveryb4a7a1f5-b9a8-4663-b1bc-96d5d0c50fa1

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