The Endocannabinoid System and Neurogenesis in Health and Disease

Galve Roperh, Ismael; Aguado Sánchez, Tania; Palazuelos Diego, Javier; Guzmán Pastor, Manuel

The Endocannabinoid System and Neurogenesis in Health and Disease

Official URL

https://doi.org/10.1177/1073858406296407

Publication date

2007

Authors

Galve Roperh, Ismael

Aguado Sánchez, Tania

Palazuelos Diego, Javier

Guzmán Pastor, Manuel

Publisher

SAGE Publications

Citations

Exportar

URI

https://hdl.handle.net/20.500.14352/91585

Citation

Galve-Roperh I, Aguado T, Palazuelos J, Guzmán M. The Endocannabinoid System and Neurogenesis in Health and Disease. The Neuroscientist. 2007;13(2):109-114. doi:10.1177/1073858406296407

Abstract

The endocannabinoid system exerts an important neuromodulatory function in different brain areas and is also known to be involved in the regulation of neural cell fate. Thus, CB1 cannabinoid receptors are neuroprotective in different models of brain injury, and their expression is altered in various neurodegenerative diseases. Recent findings have demonstrated the presence of a functional endocannabinoid system in neural progenitor cells that participates in the regulation of cell proliferation and differentiation. In this Research Update, the authors address the experimental evidence regarding the regulatory role of cannabinoids in neurogenesis and analyze them in the context of those pathological disorders in which cannabinoid function and altered neuronal or glial generation is most relevant, for example, stroke and multiple sclerosis.