Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens

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dc.contributor.authorBarreiro, Pablo
dc.contributor.authorCandel González, Francisco Javier
dc.contributor.authorSanz, Juan Carlos
dc.contributor.authorSan Román Montero, Jesús
dc.contributor.authordel Mar Carretero, María
dc.contributor.authorPérez Abeledo, Marta
dc.contributor.authorRamos, Belén
dc.contributor.authorViñuela Prieto, José Manuel
dc.contributor.authorCanora, Jesús
dc.contributor.authorMartínez Peromingo, Francisco Javier
dc.contributor.authorZapatero, Antonio
dc.date.accessioned2023-06-17T08:32:34Z
dc.date.available2023-06-17T08:32:34Z
dc.date.issued2021-05-10
dc.descriptionThis research was funded by the Council of Health, Community of Madrid.
dc.description.abstractThe virological meaning of the different patterns of serology in COVID-19 has been little examined in clinical settings. Asymptomatic subjects with IgM-spike (S) and IgG-nucleocapsid (N) determinations by chemiluminescence were studied for SARS-CoV-2 shedding in respiratory secretions by transcription-mediated amplification (TMA). In subjects showing IgM-S positive and IgG-N negative, IgG-S was determined by lateral flow assay. A total of 712 individuals were tested: 30.0% presented IgM-S(+)/IgG-N(−), 25.8% had IgM-S(+)/IgG-N(+) and 44.2% had IgM-S(−)/IgG-N(+); the proportion with TMA(+) were comparable in these three groups: 12.1, 8.7 and 10.5%, respectively. In individuals with IgM-S(+)/IgG-N(−), IgG-S(+) was detected in 66.5%. The frequency of IgM-S(+)/IgG-S(−) in the total population was 10.0%, of whom 24.1% had TMA(+); the chances for TMA(+) in subjects with an IgM-S(+) alone pattern were 2.4%. Targeting of the same SARS-CoV-2 antigen seems to be better for the characterization of IgM/IgG patterns of response. IgM-S(+) alone reactivity is rare, and a small proportion is associated with viral shedding.
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77536
dc.identifier.doi10.3390/v13050874
dc.identifier.issn1999-4915
dc.identifier.officialurlhttps://doi.org/10.3390/v13050874
dc.identifier.relatedurlhttps://www.mdpi.com/1999-4915/13/5/874
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7403
dc.issue.number5
dc.journal.titleViruses
dc.language.isoeng
dc.page.initial874
dc.publisherMDPI
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu616.9
dc.subject.keywordSARS-CoV-2
dc.subject.keywordCOVID-19
dc.subject.keywordSerology
dc.subject.keywordIgM
dc.subject.keywordSpike
dc.subject.keywordNucleocapsid
dc.subject.ucmMedicina
dc.subject.ucmEnfermedades infecciosas
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.titleVirological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens
dc.typejournal article
dc.volume.number13
dspace.entity.typePublication
relation.isAuthorOfPublicatione3fd256a-b289-486c-b3c8-a03d2bf51295
relation.isAuthorOfPublication.latestForDiscoverye3fd256a-b289-486c-b3c8-a03d2bf51295
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