Risk factors associated with negative in-vivo diagnostic results in bovine tuberculosis-infected cattle in Spain

Simple item page
dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorPerez, Andrés
dc.contributor.authorMarqués, Sergio
dc.contributor.authorBezos Garrido, Javier
dc.contributor.authorGrau, Anna
dc.contributor.authorCruz Conty, Maria Luisa de la
dc.contributor.authorRomero Martínez, Beatriz
dc.contributor.authorSaez, Jose Luis
dc.contributor.authordel Rosario Esquivel, Maria
dc.contributor.authorMartínez, Maria del Carmen
dc.contributor.authorMínguez, Olga
dc.contributor.authorJuan Ferré, Lucía De
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.date.accessioned2023-06-19T15:04:43Z
dc.date.available2023-06-19T15:04:43Z
dc.date.issued2014-01-13
dc.description.abstractBACKGROUND Despite great effort and investment incurred over decades to control bovine tuberculosis (bTB), it is still one of the most important zoonotic diseases in many areas of the world. Test-and-slaughter strategies, the basis of most bTB eradication programs carried out worldwide, have demonstrated its usefulness in the control of the disease. However, in certain countries, eradication has not been achieved due in part to limitations of currently available diagnostic tests. In this study, results of in-vivo and post-mortem diagnostic tests performed on 3,614 animals from 152 bTB-infected cattle herds (beef, dairy, and bullfighting) detected in 2007-2010 in the region of Castilla y León, Spain, were analyzed to identify factors associated with positive bacteriological results in cattle that were non-reactors to the single intradermal tuberculin test, to the interferon-gamma (IFN-γ) assay, or to both tests applied in parallel (Test negative/Culture + animals, T-/C+). The association of individual factors (age, productive type, and number of herd-tests performed since the disclosure of the outbreak) with the bacteriology outcome (positive/negative) was analyzed using a mixed multivariate logistic regression model. RESULTS The proportion of non-reactors with a positive post-mortem result ranged from 24.3% in the case of the SIT test to 12.9% (IFN-γ with 0.05 threshold) and 11.9% (95% CI 9.9-11.4%) using both tests in parallel. Older (>4.5 years) and bullfighting cattle were associated with increased odds of confirmed bTB infection by bacteriology, whereas dairy cattle showed a significantly lower risk. Ancillary use of IFN-γ assay reduced the proportion of T-/C + animals in high risk groups. CONCLUSIONS These results demonstrate the likelihood of positive bacteriological results in non-reactor cattle is influenced by individual epidemiological factors of tested animals. Increased surveillance on non-reactors with an increased probability of being false negative could be helpful to avoid bTB persistence, particularly in chronically infected herds. These findings may aid in the development of effective strategies for eradication of bTB in Spain.
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39641
dc.identifier.doi10.1186/1746-6148-10-14
dc.identifier.issn1746-6148
dc.identifier.officialurlhttp://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-10-14
dc.identifier.urihttps://hdl.handle.net/20.500.14352/35282
dc.journal.titleBMC veterinary research
dc.language.isoeng
dc.page.initial14
dc.publisherBioMedCentral
dc.relation.projectIDTB-STEP (212414)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordTuberculosis
dc.subject.keywordCattle
dc.subject.keywordDiagnosis
dc.subject.keywordSingle tuberculin test
dc.subject.keywordInterferon-gamma assay
dc.subject.keywordRisk factors
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleRisk factors associated with negative in-vivo diagnostic results in bovine tuberculosis-infected cattle in Spain
dc.typejournal article
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublication7a0cfc93-a3f1-45bf-b529-403f216cf8f7
relation.isAuthorOfPublication2e80b9e6-3809-4756-9ef8-ebc9ce005eb8
relation.isAuthorOfPublication6b436065-5bf3-4a47-86c1-57e869d29a51
relation.isAuthorOfPublicationb460a657-8ae9-46b3-bece-0716432fcbd3
relation.isAuthorOfPublication5d5c3513-e6d9-451a-ba7d-ba0634c84bcf
relation.isAuthorOfPublication.latestForDiscovery7a0cfc93-a3f1-45bf-b529-403f216cf8f7
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
588.pdf
Size:
407.45 KB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos