Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment.

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dc.contributor.authorÁlvarez Corchado, Elena
dc.contributor.authorGonzález Ortiz, Blanca
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorDoadrio Villarejo, Antonio Luis
dc.contributor.authorColilla Nieto, Montserrat
dc.contributor.authorIzquierdo Barba, Isabel
dc.date.accessioned2023-06-16T14:25:32Z
dc.date.available2023-06-16T14:25:32Z
dc.date.issued2021-11-29
dc.descriptionRESEARCHER ID K-4773-2015 (Blanca González Ortiz) ORCID 0000-0002-0493-6071 (Blanca González Ortiz) RESEARCH ID B-5081-2017  (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID N-4628-2014 (Montse Colilla Nieto) ORCID 0000-0003-1961-4160 (Montse Colilla Nieto) RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba) ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
dc.description.abstractThis review focuses on the design of mesoporous silica nanoparticles for infection treat‐ment. Written within a general context of contributions in the field, this manuscript highlights the major scientific achievements accomplished by Prof. Vallet‐Regí’s research group in the field of silica‐based mesoporous materials for drug delivery. The aim is to bring out her pivotal role on the envisage of a new era of nanoantibiotics by using a deep knowledge on mesoporous materials as drug delivery systems and applying cutting‐edge technologies to design and engineer advanced nanoweapons to fight infection. This review has been divided in two main sections: the first part overviews the influence of the textural and chemical properties of silica‐based mesoporous materials on the loading and release of antibiotic molecules, depending on the host‐guest interactions.Furthermore, this section also remarks the potential of molecular modelling in the design and comprehension of the performance of these release systems. The second part describes the more recent advances in the use of mesoporous silica nanoparticles as versatile nanoplatforms for the development of novel targeted and stimuli‐responsive antimicrobial nanoformulations for future application in personalized infection therapies.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. Horizonte 2020
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/75589
dc.identifier.doi10.3390/pharmaceutics13122033
dc.identifier.issn1999-4923
dc.identifier.officialurlhttps://doi.org/10.3390/pharmaceutics13122033
dc.identifier.relatedurlhttps://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4999
dc.issue.number12
dc.journal.titlePharmaceutics
dc.language.isoeng
dc.page.initial2033
dc.publisherMDPI
dc.relation.projectIDVERDI (694160)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordnanoantibiotics
dc.subject.keywordmesoporous silica nanoparticles
dc.subject.keywordtargeted therapies
dc.subject.keywordstimuli-response
dc.subject.keywordinfection treatment
dc.subject.keywordmetal ions
dc.subject.ucmMateriales
dc.subject.unesco3312 Tecnología de Materiales
dc.titleNanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment.
dc.typejournal article
dc.volume.number13
dspace.entity.typePublication
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