Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients

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dc.contributor.authorAndreu-Ballester, J.C.
dc.contributor.authorArribas, M.A.
dc.contributor.authorRico, M.
dc.contributor.authorGarcía-Ballesteros, C.
dc.contributor.authorGalindo-Regal, L.
dc.contributor.authorSorando-Serra, R.
dc.contributor.authorAlbert, L.
dc.contributor.authorNavarro, A.
dc.contributor.authorLópez-Chuliá, F.
dc.contributor.authorPeydró, F.
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.date.accessioned2024-03-01T13:40:29Z
dc.date.available2024-03-01T13:40:29Z
dc.date.issued2022-02-14
dc.description.abstractImmunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emergency and Intensive Care Departments of two Hospitals, according to the latest criteria for the definition and management of sepsis. According to the severity of the septic process, there was a progressive decrease in T cells, being much more intense in γδ T cells. This decrease recovered in surviving patients, but CD3+CD56+ γδ T cells continued to decreased during hospital stay in non-surviving patients. Apoptosis increased in sepsis. Cell death of CD3+CD56+ γδ T cells progressively increased according to the severity of sepsis, especially in non-surviving patients.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationAndreu-Ballester JC, Arribas MA, Rico M, García-Ballesteros C, Galindo-Regal L, Sorando-Serra R, Albert L, Navarro A, López-Chuliá F, Peydró F, Cuéllar C. Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients. Clin Immunol. 2022 Mar;236:108956. doi: 10.1016/j.clim.2022.108956. Epub 2022 Feb 14. PMID: 35176483.
dc.identifier.doi10.1016/j.clim.2022.108956
dc.identifier.issn1521-6616
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101872
dc.journal.titleClinical Immunology
dc.language.isoeng
dc.page.initial108956
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsembargoed access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu579.6
dc.subject.cdu615.28
dc.subject.cdu576.8
dc.subject.keywordSepsis
dc.subject.keywordαβ T cells
dc.subject.keywordγδ T cell
dc.subject.keywordApoptosis
dc.subject.keywordMortality
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmMicrobiología (Farmacia)
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco2412 Inmunología
dc.titleChanges of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number236
dspace.entity.typePublication
relation.isAuthorOfPublication6c555fb4-e29c-4463-8062-a9699fcebaa6
relation.isAuthorOfPublication.latestForDiscovery6c555fb4-e29c-4463-8062-a9699fcebaa6
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