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A mouse model to identify cooperating signaling pathways in cancer.

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https://doi.org/10.1038/nmeth.2130

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2012

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Nature
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https://hdl.handle.net/20.500.14352/138061

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Musteanu M, Blaas L, Zenz R, Svinka J, Hoffmann T, Grabner B, et al. A mouse model to identify cooperating signaling pathways in cancer. Nat Methods. septiembre de 2012;9(9):897-900. doi:10.1038/nmeth.2130

Abstract

We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.

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Bioquímica (Farmacia), Biología molecular (Farmacia)

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24 Ciencias de la Vida

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