Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis

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dc.contributor.authorMontalvo Quirós, Sandra
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorPalacios, Ainhoa
dc.contributor.authorAnguita, Juan
dc.contributor.authorPrados-Rosales, Rafael C.
dc.contributor.authorGonzález Ortiz, Blanca
dc.contributor.authorLuque García, José Luis
dc.date.accessioned2024-07-09T14:45:43Z
dc.date.available2024-07-09T14:45:43Z
dc.date.issued2020-12-16
dc.description.abstractThe increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics constitute a public health issue, since tuberculosis still constitutes the primary cause of death in the world due to bacterial infection. Mtb has been shown to produce membrane-derived extracellular vesicles (EVs) containing proteins responsible for modulating the pathological immune response after infection. These natural vesicles were considered a promising alternative to the development of novel vaccines. However, their use was compromised by the observed lack of reproducibility between preparations. In this work, with the aim of developing nanosystems mimicking the extracellular vesicles produced by Mtb, mesoporous silica nanoparticles (MSNs) have been used as nanocarriers of immunomodulatory and vesicle-associated proteins (Ag85B, LprG and LprA). These novel nanosystems have been designed and extensively characterized, demonstrating the effectiveness of the covalent anchorage of the immunomodulatory proteins to the surface of the MSNs. The immunostimulatory capacity of the designed nanosystems has been demonstrated by measuring the levels of pro- (TNF) and anti-inflammatory (IL-10) cytokines in exposed macrophages. These results open a new possibility for the development of more complex nanosystems, including additional vesicle components or even antitubercular drugs, thus allowing for the combination of immunomodulatory and bactericidal effects against Mtb.
dc.description.departmentDepto. de Química Analítica
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMontalvo-Quirós, S.; Vallet-Regí, M.; Palacios, A.; Anguita, J.; Prados-Rosales, R.C.; González, B.; Luque-Garcia, J.L. Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis. Pharmaceutics 2020, 12, 1218. https://doi.org/10.3390/pharmaceutics12121218
dc.identifier.doi10.3390/pharmaceutics12121218
dc.identifier.issn1999-4923
dc.identifier.officialurlhttps://www.mdpi.com/1999-4923/12/12/1218
dc.identifier.relatedurlhttps://doi.org/10.3390/pharmaceutics12121218
dc.identifier.urihttps://hdl.handle.net/20.500.14352/105861
dc.issue.number12
dc.journal.titlePharmaceutics
dc.language.isoeng
dc.page.initial1218
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu54
dc.subject.keywordMycobacterium tuberculosis
dc.subject.keywordmesoporous silica nanoparticles
dc.subject.keywordimmunomodulatory proteins
dc.subject.keywordimmune system activation
dc.subject.keywordtuberculosis vaccines
dc.subject.ucmQuímica
dc.subject.unesco23 Química
dc.titleMesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
dc.typejournal article
dc.volume.number12
dspace.entity.typePublication
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relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
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relation.isAuthorOfPublication.latestForDiscovery33755978-b21f-4d9c-b103-0bd6cced5047
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