Boosting the Near-Infrared Emission of Ag2S Nanoparticles by a Controllable Surface Treatment for Bioimaging Applications

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dc.contributor.authorZabala Gutiérrez, Irene
dc.contributor.authorGerke, Christoph
dc.contributor.authorShen, Yingli
dc.contributor.authorXimendes, Erving Clayton
dc.contributor.authorManso Silvan, Miguel
dc.contributor.authorMarin, Riccardo
dc.contributor.authorJaque García, Daniel
dc.contributor.authorGómez Calderón, Óscar
dc.contributor.authorMelle Hernández, Sonia
dc.contributor.authorRubio Retama, Benito Jorge
dc.date.accessioned2023-06-22T10:41:25Z
dc.date.available2023-06-22T10:41:25Z
dc.date.issued2022-01
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractAg2S nanoparticles are the staple for high-resolution preclinical imaging and sensing owing to their photochemical stability, low toxicity, and photoluminescence (PL) in the second near-infrared biological window. Unfortunately, Ag2S nanoparticles exhibit a low PL efficiency attributed to their defective surface chemistry, which curbs their translation into the clinics. To address this shortcoming, we present a simple methodology that allows to improve the PL quantum yield from 2 to 10%, which is accompanied by a PL lifetime lengthening from 0.7 to 3.8 μs. Elemental mapping and X-ray photoelectron spectroscopy indicate that the PL enhancement is related to the partial removal of sulfur atoms from the nanoparticle’s surface, reducing surface traps responsible for nonradiative de-excitation processes. This interpretation is further backed by theoretical modeling. The acquired knowledge about the nanoparticles’ surface chemistry is used to optimize the procedure to transfer the nanoparticles into aqueous media, obtaining water-dispersible Ag2S nanoparticles that maintain excellent PL properties. Finally, we compare the performance of these nanoparticles with other near-infrared luminescent probes in a set of in vitro and in vivo experiments, which demonstrates not only their cytocompatibility but also their superb optical properties when they are used in vivo, affording higher resolution images.en
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.departmentSección Deptal. de Óptica (Óptica)
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipUniversidad Complutense de Madrid/Banco de Santander
dc.description.sponsorshipFondo Europeo de Desarrollo Regional
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/71638
dc.identifier.citationZabala Gutiérrez, I., Gerke, C., Shen, Y. et al. «Boosting the Near-Infrared Emission of Ag 2 S Nanoparticles by a Controllable Surface Treatment for Bioimaging Applications». ACS Applied Materials & Interfaces, vol. 14, n.o 4, febrero de 2022, pp. 4871-81. DOI.org (Crossref), https://doi.org/10.1021/acsami.1c19344.
dc.identifier.doi10.1021/acsami.1c19344
dc.identifier.issn1944-8244
dc.identifier.officialurlhttps://doi.org/10.1021/acsami.1c19344
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71386
dc.issue.number4
dc.journal.titleACS Applied Materials & Interfaces
dc.language.isoeng
dc.page.final4881
dc.page.initial4871
dc.publisherACS Publications
dc.relation.projectIDNanoTBTech (801305); SPOT (895932); LANTERNS (797945)
dc.relation.projectIDMAT2017-83111R; PID2019-106211RB-I00
dc.relation.projectIDRENIM-CM (S2017/BMD-3867)
dc.relation.projectID(CT63/19-CT64/19).
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu620.3
dc.subject.cdu57.087.3
dc.subject.cdu616-073
dc.subject.cdu539.2:620.1
dc.subject.keywordSilver sulfide
dc.subject.keywordPL enhancing
dc.subject.keywordNIR imaging
dc.subject.keywordsurface traps
dc.subject.keywordQY
dc.subject.keywordPL lifetimes
dc.subject.keywordSurface etching
dc.subject.ucmÓptica (Física)
dc.subject.ucmPartículas
dc.subject.ucmMateriales
dc.subject.ucmTécnicas de la imagen
dc.subject.unesco2209.19 Óptica Física
dc.subject.unesco2208 Nucleónica
dc.subject.unesco3312 Tecnología de Materiales
dc.titleBoosting the Near-Infrared Emission of Ag2S Nanoparticles by a Controllable Surface Treatment for Bioimaging Applicationsen
dc.typejournal article
dc.volume.number14
dspace.entity.typePublication
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relation.isAuthorOfPublication8a3278f0-4087-4446-a600-8051009d4722
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relation.isAuthorOfPublication.latestForDiscovery24f8ceb9-f02a-41ac-851f-5182f31d41a4
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