Biomimetic camouflaged nanoparticles with selective cellular internalization and migration competences

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dc.contributor.authorJiménez Jiménez, Carla
dc.contributor.authorMoreno Borrallo, Almudena
dc.contributor.authorDumontel, Bianca
dc.contributor.authorManzano, Miguel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-22T12:36:24Z
dc.date.available2023-06-22T12:36:24Z
dc.date.issued2022-12-05
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractIn the last few years, nanotechnology has revolutionized the potential treatment of different diseases. However, the use of nanoparticles for drug delivery might be limited by their immune clearance, poor biocompatibility and systemic immunotoxicity. Hypotheses for overcoming rejection from the body and increasing their biocompatibility include coating nanoparticles with cell membranes. Additionally, source cell-specific targeting has been reported when coating nanoparticles with tumor cells membranes. Here we show that coating mesoporous silica nanoparticles with membranes derived from preosteoblastic cells could be employed to develop potential treatments of certain bone diseases. These nanoparticles were selected because of their well-established drug delivery features. On the other hand MC3T3-E1 cells were selected because of their systemic migration capabilities towards bone defects. The coating process was here optimized ensuring their drug loading and delivery features. More importantly, our results demonstrated how camouflaged nanocarriers presented cellular selectivity and migration capability towards the preosteoblastic source cells, which might constitute the inspiration for future bone disease treatments.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Research Council
dc.description.sponsorshipMinisterio de Ciencia e Innovación
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/76504
dc.identifier.doi10.1016/j.actbio.2022.11.059
dc.identifier.issn17427061
dc.identifier.officialurlhttps://doi.org/10.1016/j.actbio.2022.11.059
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S1742706122007942?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72916
dc.journal.titleActa Biomaterialia
dc.language.isoeng
dc.page.final407
dc.page.initial395
dc.relation.projectID694160
dc.relation.projectIDPID2019-106436RB-I00
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.keywordNanomedicine
dc.subject.keywordCoating technology
dc.subject.keywordCell membranes
dc.subject.keywordNanocarriers for drug delivery
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco2390 Química Farmacéutica
dc.titleBiomimetic camouflaged nanoparticles with selective cellular internalization and migration competences
dc.typejournal article
dc.volume.number157
dspace.entity.typePublication
relation.isAuthorOfPublication78c9fb3f-bd15-4c15-bff0-e1f83e0df99f
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery78c9fb3f-bd15-4c15-bff0-e1f83e0df99f
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