Publication: Establecimiento de la Microbiota en Recién Nacidos: distintos Escenarios y Metodologías
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2024-04-24
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Universidad Complutense de Madrid
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Abstract
La adquisición y el establecimiento del microbioma después del nacimiento puede condicionar la salud del resto de nuestra vida. La predisposición a ciertas patologías o el agravamiento de enfermedades de base está influenciado por las bacterias y otros microorganismos que habitan en nuestro cuerpo. Conocer las dinámicas que ocurren en este complejo ecosistema es necesario para identificar terapias alternativas al uso de antibióticos bajo una perspectiva ecológica. Además, existen múltiples herramientas para abordar la complejidad de la microbiota intestinal y es necesario identificar las fortalezas y debilidades de cada aproximación, así como unificar las bases de datos y la clasificación taxonómica. Estas herramientas permiten, además, reformular conceptos como los brotes o la virulencia potencial de una bacteria, ya que exploran todo el contenido genético ,proteico o metabólico de los microorganismos en cuestión. Esta tesis tiene como principal objetivo estudiar la implantación de la microbiota de recién nacidos en diferentes circunstancias con especial vulnerabilidad, y determinar la capacidad de las bacterias depredadoras de erradicar a patógenos clínicos...
The acquisition and establishment of the microbiome after birth can affect the state of health for the rest of our lives. The predisposition to certain pathologies or the aggravation of basic diseases is influenced by the bacteria and other microorganisms that inhabit our body. Knowing the dynamics that occur in this complex ecosystem is necessary to identify alternative therapies for antibiotic usage with an ecological perspective. In addition, there are multiple tools to address the complexity of the intestinal microbiota and it is necessary to identify the strengths and weaknesses of each approach, as well as to unify databases and taxonomic classification guidelines. These tools also allow the reformulation of concepts such as outbreaks or the potential virulence of a bacterium, since they explore the entire genetic, protein or metabolic content of the microorganisms in question. The main objective of this thesis is to study the establishment of the newborn microbiota in different circumstances with special vulnerability, and to determine the capacity of predatory bacteria to eradicate clinical pathogens...
The acquisition and establishment of the microbiome after birth can affect the state of health for the rest of our lives. The predisposition to certain pathologies or the aggravation of basic diseases is influenced by the bacteria and other microorganisms that inhabit our body. Knowing the dynamics that occur in this complex ecosystem is necessary to identify alternative therapies for antibiotic usage with an ecological perspective. In addition, there are multiple tools to address the complexity of the intestinal microbiota and it is necessary to identify the strengths and weaknesses of each approach, as well as to unify databases and taxonomic classification guidelines. These tools also allow the reformulation of concepts such as outbreaks or the potential virulence of a bacterium, since they explore the entire genetic, protein or metabolic content of the microorganisms in question. The main objective of this thesis is to study the establishment of the newborn microbiota in different circumstances with special vulnerability, and to determine the capacity of predatory bacteria to eradicate clinical pathogens...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, leída el 27/04/2023