Gammadelta T cells as a predictor of surgical relapse of Crohn's disease

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dc.contributor.authorAndreu-Ballester, Juan Carlos
dc.contributor.authorCatalán-Serra, Ignacio
dc.contributor.authorGil-Borrás, Rafael
dc.contributor.authorMarqués-García, Pilar
dc.contributor.authorGarcía-Ballesteros, Carlos
dc.contributor.authorLópez Chuliá, Francisco
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.date.accessioned2024-02-19T10:20:04Z
dc.date.available2024-02-19T10:20:04Z
dc.date.issued2020-09-20
dc.description.abstractBackground: We recently demonstrated a decrease in the overall lymphocyte population in the peripheral blood of patients with CD compared to healthy controls and this decrease is more evident in γδ T lymphocytes. The percentages of T cell subsets could reflect the risk of surgical relapse in CD patients. The aim of this study is to study the correlation between αβ and γδ T cell subsets in the peripheral blood of patients with CD and the risk for surgery during follow up. Methods: A prospective study of 102 patients with CD compared with 102 healthy subjects (control group) matched by age and sex was conducted. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, and αβ and γδ T cell subsets were measured in the peripheral blood of all participants. Results: We found evidence of a relationship between lower γδ T cell levels and risk of surgical relapse in CD. The lowest subsets observed in CD patients with surgical relapse were CD3 + γδ, CD3 + CD8 + γδ and CD3 + CD56 + γδ T cells. We observed a relationship between a decrease in γδ T cells and the most severe forms of the disease. The lowest levels of CD3 + γδ and CD3 + CD8 + γδ T cells were observed in the fistulizing phenotype. Conclusions: The deficit of γδ T cells was related with the severity and the risk for surgicalrelapse in CD patients. Patients with CD3 + γδ deficit were more prone to surgery than patientswithout this deficit. These results suggest that γδ T cells could be used as markers of poorprognosis of CD following the diagnosis of the disease.eng
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationAndreu-Ballester JC, Catalán-Serra I, Gil-Borrás R, Marqués-García P, García-Ballesteros C, López Chuliá F, Cuéllar C. Gammadelta T cells as a predictor of surgical relapse of Crohn's disease. Clin Res Hepatol Gastroenterol. 2020 Sep;44(4):586-597. doi: 10.1016/j.clinre.2019.11.003. Epub 2019 Dec 18. PMID: 31864955.
dc.identifier.doi10.1016/j.clinre.2019.11.003
dc.identifier.issn2210-7401
dc.identifier.officialurlhttps://doi.org/10.1016/j.clinre.2019.11.003
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101541
dc.issue.number4
dc.journal.titleClinics and Research in Hepatology and Gastroenterology
dc.language.isoeng
dc.page.final597
dc.page.initial586
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu579.6
dc.subject.cdu615.28
dc.subject.cdu576.8
dc.subject.keywordCrohn’s Disease
dc.subject.keywordGammadelta T cells
dc.subject.keywordSurgery
dc.subject.keywordRelapse
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmMicrobiología (Farmacia)
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco3207.10 Inmunopatología
dc.titleGammadelta T cells as a predictor of surgical relapse of Crohn's disease
dc.typejournal article
dc.type.hasVersionEVoR
dc.volume.number44
dspace.entity.typePublication
relation.isAuthorOfPublication6c555fb4-e29c-4463-8062-a9699fcebaa6
relation.isAuthorOfPublication.latestForDiscovery6c555fb4-e29c-4463-8062-a9699fcebaa6
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