Publication:
Allergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring

dc.contributor.authorBenito Villalvilla, Cristina
dc.contributor.authorPérez Diego, Mario
dc.contributor.authorAngelina Querencias, Alba
dc.contributor.authorKisand, Kai
dc.contributor.authorRebane, Ana
dc.contributor.authorSubiza, José Luis
dc.contributor.authorPalomares Gracia, Oscar
dc.date.accessioned2023-06-22T10:40:20Z
dc.date.available2023-06-22T10:40:20Z
dc.date.issued2022-06-18
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2021)
dc.description.abstractAllergoid–mannan conjugates are novel vaccines for allergen-specific immunotherapy being currently assayed in phase 2 clinical trials. Allergoid–mannan conjugates target dendritic cells (DCs) and generate functional forkhead box P3 (FOXP3)-positive Treg cells, but their capacity to reprogram monocyte differentiation remains unknown.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipFondo Europeo de Desarrollo Regional (FEDER)
dc.description.sponsorshipEstonian Research Council
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/70115
dc.identifier.doi10.1016/j.jaci.2021.06.012
dc.identifier.issn0091-6749
dc.identifier.officialurlhttps://doi.org/10.1016/j.jaci.2021.06.012
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71283
dc.issue.number1
dc.journal.titleThe Journal of Allergy and Clinical Inmunology
dc.language.isoeng
dc.page.final222.e9
dc.page.initial212
dc.publisherElsevier
dc.relation.projectIDSAF-2017-84978-R; IDI-20110410 and IDI-20141131
dc.relation.projectID(Project no. 2014-2020.4.01.15-0012
dc.relation.projectIDPRG1117
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu577.1
dc.subject.keywordAllergen-specific immunotherapy
dc.subject.keywordallergoid–mannan conjugates
dc.subject.keywordmonocytes
dc.subject.keywordtolerogenic dendritic cells
dc.subject.keywordregulatory T cells
dc.subject.keywordmetabolism
dc.subject.keywordepigenetics
dc.subject.ucmQuímica
dc.subject.ucmBiología molecular (Química)
dc.subject.ucmBioquímica (Química)
dc.subject.unesco23 Química
dc.titleAllergoid–mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring
dc.typejournal article
dc.volume.number149
dspace.entity.typePublication
relation.isAuthorOfPublication3356f6c6-c499-44de-8faf-0e69c97d0167
relation.isAuthorOfPublication09f21d21-f04a-405e-8364-59a2ab83bc61
relation.isAuthorOfPublication67a57ba8-97f2-4aa6-99d3-62cfa97da7c7
relation.isAuthorOfPublication.latestForDiscovery3356f6c6-c499-44de-8faf-0e69c97d0167
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