The Immune System through the Lens of Alcohol Intake and Gut Microbiota

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dc.contributor.authorCalleja Conde, Javier
dc.contributor.authorEcheverry Alzate, Víctor
dc.contributor.authorBuhler, Kora Mareen Katharina
dc.contributor.authorDurán González, Pedro
dc.contributor.authorMorales García, José Ángel
dc.contributor.authorSegovia Rodríguez, Lucía
dc.contributor.authorRodríguez De Fonseca, Fernando Antonio
dc.contributor.authorGiné Domínguez, Elena
dc.contributor.authorLópez Moreno, José Antonio
dc.date.accessioned2023-06-16T14:22:11Z
dc.date.available2023-06-16T14:22:11Z
dc.date.issued2021-07-13
dc.description.abstractThe human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.en
dc.description.departmentSección Deptal. de Biología Celular (Medicina)
dc.description.departmentDepto. de Psicobiología y Metodología en Ciencias del Comportamiento
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Psicología
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Sanidad (España)
dc.description.sponsorshipFondo de Investigación Sanitaria (Red de Trastornos Adictivos)
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipFondo Europeo de Desarrollo Regional
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/71683
dc.identifier.citationCalleja Conde, J., Echeverry Alzate, V., Buhler, K. M. K. et al. «The Immune System through the Lens of Alcohol Intake and Gut Microbiota». International Journal of Molecular Sciences, vol. 22, n.o 14, julio de 2021, p. 7485. DOI.org (Crossref), https://doi.org/10.3390/ijms22147485.
dc.identifier.doi10.3390/ijms22147485
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms22147485
dc.identifier.pmid34299105
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/22/14/7485/htm
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/34299105/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4844
dc.issue.number7485
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.total15
dc.publisherMPDI
dc.relation.projectIDPNSD2018-050
dc.relation.projectIDRD16/0017/0008, RD16/0017/0001
dc.relation.projectIDCD17/00125
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.keywordAlcohol
dc.subject.keywordGut
dc.subject.keywordMicrobiota
dc.subject.keywordBrain
dc.subject.keywordLiver
dc.subject.keywordImmune system
dc.subject.keywordDysbiosis
dc.subject.ucmEndocrinología
dc.subject.ucmPsicología (Psicología)
dc.subject.ucmNutrición
dc.subject.unesco3205.02 Endocrinología
dc.subject.unesco61 Psicología
dc.subject.unesco3206 Ciencias de la Nutrición
dc.titleThe Immune System through the Lens of Alcohol Intake and Gut Microbiotaen
dc.typejournal article
dc.volume.number22
dspace.entity.typePublication
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