Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment

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dc.contributor.authorGonzález Ortiz, Blanca
dc.contributor.authorColilla Nieto, Montserrat
dc.contributor.authorDíez, Jaime
dc.contributor.authorPedraza, Daniel
dc.contributor.authorGuembe, Marta
dc.contributor.authorIzquierdo Barba, Isabel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-17T12:26:04Z
dc.date.available2023-06-17T12:26:04Z
dc.date.issued2018-03-01
dc.descriptionRESEARCHER ID K-4773-2015 (Blanca González Ortiz) ORCID 0000-0002-0493-6071 (Blanca González Ortiz) RESEARCHER ID N-4628-2014 (Montse Colilla Nieto) ORCID 0000-0003-1961-4160 (Montse Colilla Nieto) RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba) ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractThis work aims to provide an effective and novel solution for the treatment of infection by using nanovehicles loaded with antibiotics capable of penetrating the bacterial wall, thus increasing the antimicrobial effectiveness. These nanosystems, named "nanoantibiotics", are composed of mesoporous silica nanoparticles (MSNs), which act as nanocarriers of an antimicrobial agent (levofloxacin, LEVO) localized inside the mesopores. To provide the nanosystem of bacterial membrane interaction capability, a polycationic dendrimer, concretely the poly(propyleneimine) dendrimer of third generation (G3), was covalently grafted to the external surface of the LEVOloaded MSNs. After physicochemical characterization of this nanoantibiotic, the release kinetics of LEVO and the antimicrobial efficacy of each released dosage were evaluated. Besides, internalization studies of the MSNs functionalized with the G3 dendrimer were carried out, showing a high penetrability throughout Gram-negative bacterial membranes. This work evidences that the synergistic combination of polycationic dendrimers as bacterial membrane permeabilization agents with LEVO-loaded MSNs triggers an efficient antimicrobial effect on Gram-negative bacterial biofilm. These positive results open up very promising expectations for their potential application in new infection therapies.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. H2020
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/45947
dc.identifier.doi10.1016/j.actbio.2017.12.041
dc.identifier.issn1742-7061
dc.identifier.officialurlhttps://www.elsevier.com/
dc.identifier.relatedurlhttp://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/11951
dc.journal.titleActa Biomaterialia
dc.language.isoeng
dc.page.final271
dc.page.initial261
dc.publisherElsevie
dc.relation.projectIDVERDI (694160)
dc.relation.projectIDMAT2013-43299-R
dc.relation.projectIDMAT2015-64831-R
dc.relation.projectIDMAT2016-75611-R AEI/FEDER
dc.relation.projectIDgrant PI15/00978
dc.rights.accessRightsopen access
dc.subject.cdu546
dc.subject.cdu615.46
dc.subject.cdu616.9
dc.subject.keywordMesoporous Silica Nanoparticles
dc.subject.keywordPolycationic dendrimers
dc.subject.keywordBacterial internalization
dc.subject.keywordAntimicrobial delivery
dc.subject.keywordBiofilm
dc.subject.keywordInfection treatment
dc.subject.ucmMateriales
dc.subject.ucmEnfermedades infecciosas
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco3312 Tecnología de Materiales
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.titleMesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment
dc.typejournal article
dc.volume.number68
dspace.entity.typePublication
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relation.isAuthorOfPublication449a114d-e3bf-4d4c-81c5-2b0c5f050b9d
relation.isAuthorOfPublicationee9272a2-db11-4efb-97f8-7ce1a18ad55e
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery997950d3-5fce-4339-adc2-4f6ff011cd18
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