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Chronic Venous Disease in Pregnant Women Causes an Increase in ILK in the Placental Villi Associated with a Decrease in E-Cadherin

dc.contributor.authorOrtega, Miguel A.
dc.contributor.authorChaowen, Chen
dc.contributor.authorFraile Martínez, Oscar
dc.contributor.authorGarcía Montero, Cielo
dc.contributor.authorSáez García, Miguel Ángel
dc.contributor.authorCruza, Iris
dc.contributor.authorPereda Cerquella, Claude
dc.contributor.authorÁlvarez Mon, Miguel Ángel
dc.contributor.authorGuijarro, Luis G.
dc.contributor.authorFatych, Yuliia
dc.contributor.authorMenor Salván, César
dc.contributor.authorÁlvarez Mon, Melchor
dc.contributor.authorLeón Luis, Juan Antonio
dc.contributor.authorBuján, Julia
dc.contributor.authorGarcía Honduvilla, Natalio
dc.contributor.authorBravo Arribas, Coral
dc.contributor.authorAsúnsolo del Barco, Angel
dc.date.accessioned2023-06-22T12:57:08Z
dc.date.available2023-06-22T12:57:08Z
dc.date.issued2022-02-14
dc.description.abstractChronic venous disease (CVD) is a multifactorial vascular disorder frequently manifested in lower limbs in the form of varicose veins (VVs). Women are a vulnerable population for suffering from CVD, especially during pregnancy, when a plethora of changes occur in their cardiovascular system. Previous studies have indicated a worrisome association between CVD in pregnancy with the placental structure and function. Findings include an altered cellular behavior and extracellular matrix (ECM) composition. Integrin-linked kinase (ILK) is a critical molecule involved in multiple physiological and pathological conditions, and together with cadherins, is essential to mediate cell to ECM and cell to cell interplay, respectively. Thus, the aim of this study was to evaluate the implication of ILK and a set of cadherins (e-cadherin, cadherin-6 and cadherin-17) in placentas of women with CVD in order to unravel the possible pathophysiological role of these components. Gene expression (RT-qPCR) and protein expression (immunohistochemistry) studies were performed. Our results show a significant increase in the gene and protein expression of ILK, cadherin-6 and cadherin-17 and a decrease of e-cadherin in the placenta of women with CVD. Overall, this work shows that an abnormal expression of ILK, e-cadherin, cadherin-6 and cadherin-17 may be implicated in the pathological changes occurring in the placental tissue. Further studies should be conducted to determine the possible associations of these changes with maternal and fetal well-being.
dc.description.departmentDepto. de Salud Pública y Materno - Infantil
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipHalekulani S.L.
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77839
dc.identifier.doi10.3390/jpm12020277
dc.identifier.issn2075-4426
dc.identifier.officialurlhttps://doi.org/10.3390/jpm12020277
dc.identifier.relatedurlhttps://www.mdpi.com/2075-4426/12/2/277
dc.identifier.urihttps://hdl.handle.net/20.500.14352/73358
dc.issue.number2
dc.journal.titleJournal of Personalized Medicine
dc.language.isoeng
dc.page.initial277
dc.publisherMDPI
dc.relation.projectIDFEDER
dc.relation.projectIDB2017/BMD-3804 MITIC-CM, B2020/MITICAD-CM
dc.relation.projectIDPlan Estatal de I + D+I 2013–2016 (FIS-PI18/00912, PI21/01244)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu618.2
dc.subject.keywordChronic venous disease (CVD)
dc.subject.keywordPregnancy
dc.subject.keywordIntegrin-linked kinase (ILK)
dc.subject.keywordCadherins
dc.subject.keywordCell behavior
dc.subject.keywordExtracellular matrix (ECM)
dc.subject.ucmMedicina
dc.subject.ucmGinecología y obstetricia
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3201.08 Ginecología
dc.titleChronic Venous Disease in Pregnant Women Causes an Increase in ILK in the Placental Villi Associated with a Decrease in E-Cadherin
dc.typejournal article
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublicationc0bd9c40-5b4f-4f42-8904-9f8d22fe68d0
relation.isAuthorOfPublicatione2778567-7775-46c0-b81b-1f4f22c18a6c
relation.isAuthorOfPublication.latestForDiscoveryc0bd9c40-5b4f-4f42-8904-9f8d22fe68d0

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