Psychiatric disturbances in radiologically isolated syndrome
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2015
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Labiano-Fontcuberta, A., Aladro, Y., Martínez-Ginés, M. L., Ayuso, L., Mitchell, A. J., Puertas, V., Cerezo, M., Higueras, Y., & Benito-León, J. (2015). Psychiatric disturbances in radiologically isolated syndrome. Journal of Psychiatric Research, 68, 309-315. https://doi.org/10.1016/J.JPSYCHIRES.2015.05.008
Abstract
Background: Radiologically isolated syndrome (RIS) is characterized by incidental lesions suggestive of multiple sclerosis (MS) on MRI without typical symptoms of MS. Clinically isolated syndrome (CIS) is characterized by a first episode of neurologic symptoms caused by demyelination in the central nervous system. To date, psychiatric disorders have not been systematically addressed in RIS subjects. We assessed emotional disturbances, personality features and health-related quality of life (HRQoL) in a cohort of RIS patients as compared with clinically isolated syndrome (CIS). Methods: Twenty-eight RIS patients, 25 clinically isolated syndrome (CIS) patients, and 22 healthy subjects were enrolled in the study. Participants were administered a mood scale (Hamilton Depression Rating Scale), behavioural measures (Personality Assessment Inventory), and fatigue measures (Fatigue Impact Scale for Daily Use). HRQoL was quantified using the EuroQol-5. Results: 14 (50%) of RIS patients had clinically significant depression, with over one-third of these having moderate depression, scores virtually identical to those observed in CIS patients. 11 of 28 (39.3%) subjects with RIS had anxious depression, a figure three times higher than that found in CIS patients. RIS patients' HAMD-17 total score showed a very strong correlation with severity of fatigue. In addition, RIS patients reported lower HRQoL (p=0.036) and a significantly higher symptoms load for somatisation compared to both CIS and control groups (p<0.002). Conclusion: RIS patients had high rates of depression, particularly anxious depression and somatization. Future studies are warranted to clarify whether these psychiatric disturbances are causally associated with a distinct white matter psychopathologic process.
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Dr. Benito-Leon is supported by the National Institutes of Health, Bethesda, MD, USA (R01 NS039422), the Commission of the European Union (grant ICT-2011-287739, NeuroTREMOR), and the Spanish Health Research Agency (grant FIS PI12/01602).
Referencias bibliográficas:
• Aaseth K., Grande R.B., Leiknes K.A., Benth J.S., Lundqvist C., Russell M.B. Personality traits and psychological distress in persons with chronic tension-type headache. The Akershus study of chronic headache. Acta Neurol Scand 2011, 124:375-382.
• Amato M.P., Hakiki B., Goretti B., Rossi F., Stromillo M.L., Giorgio A., et al. Association of MRI metrics and cognitive impairment in radiologically isolated syndromes. Neurology 2012, 78:309-314.
• American Psychiatric Association Diagnostic and statistical manual of mental disorders 2013, Washington, DC. 5th ed.
• Aronson K.R., Barrett L.F., Quigley K. Emotional reactivity and the overreport of somatic symptoms: somatic sensitivity or negative reporting style?. JPsychosom Res 2006, 60:521-530.
• Barkhof F., Filippi M., Miller D.H., Scheltens P., Campi A., Polman C.H., et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain: A J Neurol 1997, 120(Pt 11):2059-2069.
• Benito-León J., Morales J.M., Rivera-Navarro J., Mitchell A. Areview about the impact of multiple sclerosis on health-related quality of life. Disabil Rehabil 2003, 25:1291-1303.
• Benito-León J., Mitchell A.J., Rivera-Navarro J., Morales-González J.M. Impaired health-related quality of life predicts progression of disability in multiple sclerosis. Eur J Neurol 2013, 20:79-86.
• Benito-León J., Martínez-Martín P., Frades B., Martínez-Gines M.L., de Andrés C., Meca-Lallana J.E., et al. Impact of fatigue in multiple sclerosis: the Fatigue Impact Scale for Daily Use (D-FIS). Mult Scler 2007, 13:645-651.
• Berg D., Supprian T., Thomae J., Warmuth-Metz M., Horowski A., Zeiler B., et al. Lesion pattern in patients with multiple sclerosis and depression. Mult Scler 2000, 6:156-162.
• Chwastiak L., Ehde D.M., Gibbons L.E., Sullivan M., Bowen J.D., Kraft G.H. Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatry 2002, 159:1862-1868.
• Dalton E.J., Heinrichs R.W. Depression in multiple sclerosis: a quantitative review of the evidence. Neuropsychology 2005, 19:152-158.
• Di Legge S., Piattella M.C., Pozzilli C., Pantano P., Caramia F., Pestalozza I.F., et al. Longitudinal evaluation of depression and anxiety in patients with clinically isolated syndrome at high risk of developing early multiple sclerosis. Mult Scler 2003, 9:302-306.
• EuroQol G. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy 1990, 16:199-208.
• Fava M., Alpert J.E., Carmin C.N., Wisniewski S.R., Trivedi M.H., Biggs M.M., et al. Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D. Psychol Med 2004, 34:1299-1308.
• Fava M., Rush A.J., Alpert J.E., Balasubramani G.K., Wisniewski S.R., Carmin C.N., et al. Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. Am J Psychiatry 2008, 165:342-351.
• Feinstein A., O'Connor P., Akbar N., Moradzadeh L., Scott C.J., Lobaugh N.J. Diffusion tensor imaging abnormalities in depressed multiple sclerosis patients. Mult Scler 2010, 16:189-196.
• Feinstein A., Roy P., Lobaugh N., Feinstein K., O'Connor P., Black S. Structural brain abnormalities in multiple sclerosis patients with major depression. Neurology 2004, 62:586-590.
• Gold S.M., O'Connor M.F., Gill R., Kern K.C., Shi Y., Henry R.G., et al. Detection of altered hippocampal morphology in multiple sclerosis-associated depression using automated surface mesh modeling. Hum Brain Mapp 2014, 35:30-37.
• Granberg T., Martola J., Kristoffersen-Wiberg M., Aspelin P., Fredrikson S. Radiologically isolated syndrome-incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review. Mult Scler 2013, 19:271-280.
• Hamilton M. Arating scale for depression. J Neurol Neurosurg Psychiatry 1960, 23:56-62.
• Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983, 33:1444-1452.
• Lebrun C., Bensa C., Debouverie M., De Seze J., Wiertlievski S., Brochet B., et al. Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile. JNeurol, Neurosurg Psychiatry 2008, 79:195-198.
• Lebrun C., Bensa C., Debouverie M., Wiertlevski S., Brassat D., de Seze J., et al. Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients. Arch Neurol 2009, 66:841-846.
• Lebrun C., Blanc F., Brassat D., Zephir H., de Seze J. Cfsep. Cognitive function in radiologically isolated syndrome. Mult Scler 2010, 16:919-925.
• Liu S., Kullnat J., Bourdette D., Simon J., Kraemer D.F., Murchison C., et al. Prevalence of brain magnetic resonance imaging meeting Barkhof and McDonald criteria for dissemination in space among headache patients. Mult Scler 2013, 19:1101-1105.
• Lynch S.G., Kroencke D.C., Denney D.R. The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope. Mult Scler 2001, 7:411-416.
• Maia A.C., Rocha A.J., Barros B.R., Tilbery C.P. Incidental demyelinating inflammatory lesions in asymptomatic patients: a Brazilian cohort with radiologically isolated syndrome and a critical review of current literature. Arq Neuropsiquiatr 2012, 70:5-11.
• Martínez-Martín P., Catalán M.J., Benito-León J., Moreno A.O., Zamarbide I., Cubo E., et al. Impact of fatigue in Parkinson's disease: the Fatigue Impact Scale for Daily Use (D-FIS). Qual life Res 2006, 15:597-606.
• Mitchell A.J., Benito-León J., González J.M., Rivera-Navarro J. Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing. Lancet Neurol 2005, 4:556-566.
• Morey L.C. An interpretive guide to the Personality Assessment Inventory (PAI) 1996, Psychological Assessment Resources, Odessa, Fla.
• Mowbray R.M. The Hamilton rating scale for depression: a factor analysis. Psychol Med 1972, 2:272-280.
• Okuda D.T., Mowry E.M., Beheshtian A., Waubant E., Baranzini S.E., Goodin D.S., et al. Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology 2009, 72:800-805.
• Okuda D.T., Mowry E.M., Cree B.A., Crabtree E.C., Goodin D.S., Waubant E., et al. Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome. Neurology 2011, 76:686-692.
• Okuda D.T., Siva A., Kantarci O., Inglese M., Katz I., Tutuncu M., et al. Radiologically isolated syndrome: 5-year risk for an initial clinical event. PloS One 2014, 9:e90509.
• Siva A., Saip S., Altintas A., Jacob A., Keegan B.M., Kantarci O.H. Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease. Mult Scler 2009, 15:918-927.
• Strine T.W., Hootman J.M., Chapman D.P., Okoro C.A., Balluz L. Health-related quality of life, health risk behaviors, and disability among adults with pain-related activity difficulty. Am J Public Health 2005, 95:2042-2048.
• Stromillo M.L., Giorgio A., Rossi F., Battaglini M., Hakiki B., Malentacchi G., et al. Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome. Neurology 2013, 80:2090-2094.
• Swanton J.K., Fernando K., Dalton C.M., Miszkiel K.A., Thompson A.J., Plant G.T., et al. Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes. JNeurol, Neurosurg Psychiatry 2006, 77:830-833.
• Tintoré M., Rovira A., Martínez M.J., Río J., Díaz-Villoslada P., Brieva L., et al. Isolated demyelinating syndromes: comparison of different MR imaging criteria to predict conversion to clinically definite multiple sclerosis. AJNR Am J Neuroradiol 2000, 21:702-706.
• Wiethoff K., Bauer M., Baghai T.C., Moller H.J., Fisher R., Hollinde D., et al. Prevalence and treatment outcome in anxious versus nonanxious depression: results from the German Algorithm Project. JClin Psychiatry 2010, 71:1047-1054.
• Zimmerman M., Martinez J.H., Young D., Chelminski I., Dalrymple K. Severity classification on the Hamilton depression rating scale. JAffect Disord 2013, 150:384-388.
• Zorzon M., Zivadinov R., Nasuelli D., Ukmar M., Bratina A., Tommasi M.A., et al. Depressive symptoms and MRI changes in multiple sclerosis. Eur J Neurol 2002, 9:491-496.