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Effects of Intraoperative Infusion of Esmolol on Systemic and Pulmonary Inflammation in a Porcine Experimental Model of Lung Resection Surgery

dc.contributor.authorGarutti Martínez, Ignacio
dc.contributor.authorRancán, Lisa
dc.contributor.authorAbubakra, Selma
dc.contributor.authorSimón Adiego, Carlos María
dc.contributor.authorParedes Royano, Sergio Damián
dc.contributor.authorOrtega, Javier
dc.contributor.authorHuerta Martínez, Luis Javier
dc.contributor.authorNieva Ramos, Silvia
dc.contributor.authorVara Ameigeiras, Elena María
dc.date.accessioned2024-01-15T15:33:26Z
dc.date.available2024-01-15T15:33:26Z
dc.date.issued2019
dc.description.abstractBackground: Lung resection surgery (LRS) is associated with systemic and pulmonary inflammation, which can affect postoperative outcomes. Activation of β-adrenergic receptors increases the expression of proinflammatory and anti-inflammatory mediators, and their blockade may attenuate the systemic inflammatory response. The aim of this study was to analyze the effect of a continuous perioperative intravenous perfusion of esmolol on postoperative pulmonary edema in an experimental model of LRS requiring periods of one-lung ventilation (OLV). Methods: Twenty-four large white pigs were randomly assigned to 3 groups: control (CON), esmolol (ESM), and sham. The ESM group received an intravenous esmolol bolus (0.5 mg/kg) and then an esmolol infusion (0.05 mg·kg·minute) throughout the procedure. The CON group received the same volume of 0.9% saline solution as the ESM group plus a continual infusion of saline. The sham group underwent a left thoracotomy without LRS or OLV. At the end of the LRS, the animals were awakened, and after 24 hours, they underwent general anesthesia again. Lung biopsies and plasma samples were obtained to analyze the levels and expression of inflammatory mediators, and the animals also received a bronchoalveolar lavage. Results: At 24 hours after the operation, the ESM group had less lung edema and lower expression of the proinflammatory biomarkers tumor necrosis factor (TNF) and interleukin (IL)-1 compared to the CON group for both lung lobes. For the mediastinal lobe biopsies, the mean difference and 95% confidence interval (CI) between the groups for edema, TNF, and IL-1 were 14.3 (95% CI, 5.6-23.1), P = .002; 0.19 (95% CI, 0.07-0.32), P = .002; and 0.13 (95% CI, 0.04-0.22), P = .006, respectively. In the left upper lobe, the mean differences for edema, TNF, and IL-1 were 12.4 (95% CI, 4.2-20.6), P = .003; 0.25 (95% CI, 0.12-0.37), P < .001; and 0.3 (95% CI, 0.08-0.53), P = .009. Conclusions: Our results suggest that esmolol reduces lung edema and inflammatory responses in the intraoperative and postoperative periods in animals that underwent LRS with OLV.en
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.identifier.citationGarutti, Ignacio, et al. «Effects of Intraoperative Infusion of Esmolol on Systemic and Pulmonary Inflammation in a Porcine Experimental Model of Lung Resection Surgery». Anesthesia & Analgesia, vol. 128, n.o 1, enero de 2019, pp. 168-75. DOI.org (Crossref), https://doi.org/10.1213/ANE.0000000000003737.
dc.identifier.doi10.1213/ane.0000000000003737
dc.identifier.issn0003-2999
dc.identifier.officialurlhttps://doi.org/10.1213/ane.0000000000003737
dc.identifier.relatedurlhttps://journals.lww.com/anesthesia-analgesia/fulltext/2019/01000/effects_of_intraoperative_infusion_of_esmolol_on.26.aspx
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93160
dc.issue.number1
dc.journal.titleAnesthesia & Analgesia
dc.language.isoeng
dc.page.final175
dc.page.initial168
dc.publisherInternational Anesthesia Research Society
dc.relation.projectIDGrant FIS PI10/01900
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu61
dc.subject.cdu617-089.5
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco2403 Bioquímica
dc.titleEffects of Intraoperative Infusion of Esmolol on Systemic and Pulmonary Inflammation in a Porcine Experimental Model of Lung Resection Surgeryen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number128
dspace.entity.typePublication
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