The global distribution and environmental drivers of the soil antibiotic resistome

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dc.contributor.authorDelgado-Baquerizo, Manuel
dc.contributor.authorHu, Hang-Wei
dc.contributor.authorMaestre, Fernando T.
dc.contributor.authorGuerra, Carlos A.
dc.contributor.authorEisenhauer, Nico
dc.contributor.authorEldridge, David J.
dc.contributor.authorZhu, Yong-Guan
dc.contributor.authorChen, Qing-Lin
dc.contributor.authorTrivedi, Pankaj
dc.contributor.authorDu, Shuai
dc.contributor.authorMakhalanyane, Thulani P.
dc.contributor.authorVerma, Jay Prakash
dc.contributor.authorGozalo, Beatriz
dc.contributor.authorOchoa, Victoria
dc.contributor.authorAsensio, Sergio
dc.contributor.authorWang, Ling
dc.contributor.authorZaady, Eli
dc.contributor.authorIllán, Javier G.
dc.contributor.authorSiebe, Christina
dc.contributor.authorGrebenc, Tine
dc.contributor.authorZhou, Xiaobing
dc.contributor.authorLiu, Yu-Rong
dc.contributor.authorBamigboye, Adebola R.
dc.contributor.authorBlanco-Pastor, José L.
dc.contributor.authorDuran, Jorge
dc.contributor.authorRodríguez, Alexandra
dc.contributor.authorMamet, Steven
dc.contributor.authorAlfaro, Fernando
dc.contributor.authorAbades, Sebastian
dc.contributor.authorLópez Teixido, Alberto
dc.contributor.authorPeñaloza-Bojacá, Gabriel F.
dc.contributor.authorMolina-Montenegro, Marco A.
dc.contributor.authorTorres-Díaz, Cristian
dc.contributor.authorPérez, Cecilia
dc.contributor.authorGallardo, Antonio
dc.contributor.authorGarcía-Velázquez, Laura
dc.contributor.authorHayes, Patrick E.
dc.contributor.authorNeuhauser, Sigrid
dc.contributor.authorHe, Ji-Zheng
dc.date.accessioned2024-01-22T18:48:41Z
dc.date.available2024-01-22T18:48:41Z
dc.date.issued2022
dc.descriptionFunding This project received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement 702057 (CLIMIFUN), a Large Research Grant from the British Ecological Society (agreement no. LRA17\1193; MUSGONET), and from the European Research Council (ERC grant agreement no. 647038, BIODESERT). M. D. B. was also supported by a Ramón y Cajal grant (RYC2018-025483-I). M.D-B. also acknowledges support from the Spanish Ministry of Science and Innovation for the I+D+i project PID2020-115813RA-I00 funded by MCIN/AEI/10.13039/501100011033. M.D-B. is also supported by a project of the Fondo Europeo de Desarrollo Regional (FEDER) and the Consejería de Transformación Económica, Industria, Conocimiento y Universidades of the Junta de Andalucía (FEDER Andalucía 2014-2020 Objetivo temático “01 - Refuerzo de la investigación, el desarrollo tecnológico y la innovación”) associated with the research project P20_00879 (ANDABIOMA). FTM acknowledges support from Generalitat Valenciana (CIDEGENT/2018/041). J. Z. H and H. W. H. are financially supported by Australian Research Council (DP210100332). We also thank the project CTM2015-64728-C2-2-R from the Ministry of Science of Spain. C. A. G. and N. E. acknowledge funding by the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, funded by the German Research Foundation (FZT 118). TG was financially supported by Slovenian Research Agency (P4-0107, J4-3098 and J4-4547).
dc.description.abstractBackground Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.
dc.description.departmentDepto. de Biodiversidad, Ecología y Evolución
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.statuspub
dc.identifier.doi10.1186/s40168-022-01405-w
dc.identifier.essn2049-2618
dc.identifier.officialurlhttps://www.doi.org/10.1186/s40168-022-01405-w
dc.identifier.relatedurlhttps://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01405-w
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94542
dc.issue.number219
dc.journal.titleMicrobiome
dc.language.isoeng
dc.publisherBMC
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu631.4
dc.subject.keywordAntibiotic resistance
dc.subject.keywordGlobal scale
dc.subject.keywordMobile genetic elements
dc.subject.keywordHuman health
dc.subject.keywordGlobal change
dc.subject.ucmGenética
dc.subject.ucmEcología (Biología)
dc.subject.ucmEdafología (Biología)
dc.subject.unesco2417.14 Genética Vegetal
dc.subject.unesco2511.02 Biología de Suelos
dc.titleThe global distribution and environmental drivers of the soil antibiotic resistome
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublicationc4eef792-c337-48bb-913f-277cafa73c61
relation.isAuthorOfPublication.latestForDiscoveryc4eef792-c337-48bb-913f-277cafa73c61
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