Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions

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dc.contributor.authorArcos Navarrete, Daniel
dc.contributor.authorGómez Cerezo, María Natividad
dc.contributor.authorSaiz-Pardo Sanz, Melchor
dc.contributor.authorPablo Velasco, David de
dc.contributor.authorOrtega Medina, Luis
dc.contributor.authorEnciso, Silvia
dc.contributor.authorFernández Tomé, Blanca
dc.contributor.authorDíaz Güemes, Idoia
dc.contributor.authorSánchez Margallo, Francisco Miguel
dc.contributor.authorCasarrubios Palomar, Luis
dc.contributor.authorFeito Castellano, María José
dc.contributor.authorPortolés Pérez, María Teresa
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-22T11:05:50Z
dc.date.available2023-06-22T11:05:50Z
dc.date.issued2022-08-03
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022) RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete) ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete) RESEARCHER ID U-1678-2017 (María Teresa Portolés Pérez) ORCID 0000-0002-9681-0184 (María Teresa Portolés Pérez) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractThe osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a high surface area and the ability to incorporate the anti-osteoporotic drug ipriflavone. In vitro expression of the pro-inflammatory genes NF-κB1, IL-6, TNF-α, P38 and NOS2 in RAW-264.7 macrophages, indicates that these nanoparticles do not show adverse inflammatory effects. An injectable system has been prepared by suspending MBNPs in a hyaluronic acid-based hydrogel, which has been injected intraosseously into cavitary bone defects in osteoporotic rabbits. The histological analyses evidenced that MBNPs promote bone regeneration with a moderate inflammatory response. The incorporation of ipriflavone into these nanoparticles resulted in a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.departmentSección Deptal. de Fisiología (Farmacia)
dc.description.departmentDepto. de Medicina Legal, Psiquiatría y Patología
dc.description.facultyFac. de Ciencias Químicas
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. Horizonte 2020
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/74872
dc.identifier.doi10.1016/j.actbio.2022.07.067
dc.identifier.issn1742-7061
dc.identifier.officialurlhttps://doi.org/10.1016/j.actbio.2022.07.067
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72100
dc.journal.titleActa Biomaterialia
dc.language.isoeng
dc.page.final511
dc.page.initial501
dc.publisherElsevier
dc.relation.projectIDVERDI (694160)
dc.relation.projectIDMAT2016–75611-R; PID2020–11709RB-I00
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.keywordMesoporous bioactive nanoparticles
dc.subject.keywordOsteoporosis
dc.subject.keywordBone regeneration
dc.subject.keywordIpriflavone
dc.subject.keywordHyaluronic acid
dc.subject.ucmSistema musculoesquelético
dc.subject.ucmBioquímica (Farmacia)
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco2411.10 Fisiología del Músculo
dc.subject.unesco2390 Química Farmacéutica
dc.titleInjectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions
dc.typejournal article
dc.volume.number151
dspace.entity.typePublication
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