New and Old Key Players in Liver Cancer

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dc.contributor.authorCuesta Martínez, Ángel
dc.contributor.authorPalao, Nerea
dc.contributor.authorBragado Domingo, Paloma
dc.contributor.authorGutiérrez Uzquiza, Álvaro
dc.contributor.authorHerrera González, Blanca María
dc.contributor.authorSánchez Muñoz, Aranzazu
dc.contributor.authorPorras Gallo, María Almudena
dc.contributor.editorArechederra, Maria
dc.contributor.editorTarantino, Giovanni
dc.contributor.editorBerasain, Carmen
dc.date.accessioned2024-06-11T11:09:44Z
dc.date.available2024-06-11T11:09:44Z
dc.date.issued2023-12-05
dc.description.abstractLiver cancer represents a major health problem worldwide with growing incidence and high mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely the cellular origin of most HCCs through the accumulation of genetic alterations, although hepatic progenitor cells (HPCs) might also be candidates in specific cases, as discussed here. HCC usually develops in a context of chronic inflammation, fibrosis, and cirrhosis, although the role of fibrosis is controversial. The interplay between hepatocytes, immune cells and hepatic stellate cells is a key issue. This review summarizes critical aspects of the liver tumor microenvironment paying special attention to platelets as new key players, which exert both pro- and anti-tumor effects, determined by specific contexts and a tight regulation of platelet signaling. Additionally, the relevance of specific signaling pathways, mainly HGF/MET, EGFR and TGF-β is discussed. HGF and TGF-β are produced by different liver cells and platelets and regulate not only tumor cell fate but also HPCs, inflammation and fibrosis, these being key players in these processes. The role of C3G/RAPGEF1, required for the proper function of HGF/MET signaling in HCC and HPCs, is highlighted, due to its ability to promote HCC growth and, regulate HPC fate and platelet-mediated actions on liver cancer.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Educación y Cultura
dc.description.sponsorshipMinisterio de Economía y Competitividad
dc.description.statuspub
dc.identifier.citationCuesta, Á.M.; Palao, N.; Bragado, P.; Gutierrez-Uzquiza, A.; Herrera, B.; Sánchez, A.; Porras, A. New and Old Key Players in Liver Cancer. Int. J. Mol. Sci. 2023, 24, 17152. https://doi.org/10.3390/ijms242417152
dc.identifier.doi10.3390/ijms242417152
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms242417152
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/24/24/17152
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104837
dc.issue.number24
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.initial17152
dc.publisherMDPI
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137717OB-C21/ES/ENTENDER COMO REGULA C3G EL METABOLISMO HEPATICO Y TUMORAL, Y SU IMPACTO EN EL MICROENTORNO TUMORAL. MEDIADORES DEL EFECTO DEL C3G PLAQUETARIO EN CANCER DE HIGADO
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104143RB-C22/ES/NUEVAS FUNCIONES DE C3G EN LA PROGRESION TUMORAL Y FISIOLOGIA DEL HIGADO. IMPLICACION DE C3G PLAQUETARIA EN LA RESPUESTA AL DAÑO HEPATICO/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104991RB-I00/ES/DESCIFRANDO LA FUNCIÓN DE LAS NEUROPILINAS Y LAS PLEXINAS EN LA REGULACIÓN DEL DESTINO CELULAR DE LAS CÉLULAS TUMORALES DISEMINADAS Y LA FORMACION DE METÁSTASIS
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117650RA-I00/ES/USO DE LA TECNOLOGIA CRISPR%2FCAS9 PARA LA IDENTIFICACION DE NUEVOS MARCADORES METASTASICOS EN CANCER DE PROSTATA /
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124830OB-I00/ES/LAS CÉLULAS PROGENITORAS HEPÁTICAS COMO DIANA DE LA VÍA HGF/MET
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616-006.04
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.keywordliver cancer
dc.subject.keywordtumor microenvironment; platelets
dc.subject.keywordHGF
dc.subject.keywordMET
dc.subject.keywordEGFR
dc.subject.keywordTGF-β
dc.subject.keywordC3G/RAPGEF1
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmBioquímica (Farmacia)
dc.subject.unesco32 Ciencias Médicas
dc.titleNew and Old Key Players in Liver Cancer
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number24
dspace.entity.typePublication
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