Estudio serológico del herpesvirus humano tipo 6 en pacientes con esclerosis múltiple
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2018
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05/02/2018
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Universidad Complutense de Madrid
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Abstract
La Esclerosis Múltiple (EM) es una enfermedad inflamatoria crónica desmielinizante y neurodegenerativa que afecta selectivamente al Sistema Nervioso Central (SNC). Fundamentalmente se desarrolla en adultos jóvenes (25-30 años) y se caracteriza por la aparición de lesiones focales en la sustancia blanca (placas), en las que se puede observar desmielinización y destrucción axonal en grado variable con infiltración de gran número de células inflamatorias. En la formación y progresión de la lesión inflamatoria, participan tanto los linfocitos T, actuando sobre el parénquima cerebral tras atravesar la barrera hematoencefálica, como los linfocitos B, que contribuyen al proceso de desmielinización mediante la secreción de anticuerpos...
Multiple Sclerosis (MS) is a demyelinating and neurodegenerative chronic inflammatory disease that selectively affects the central nervous system (CNS). Mainly it develops in young adults (25-30 years) and is characterized by the appearance of focal lesions in the white matter (plaques). In these lesions demyelination and axonal destruction can be observed with infiltration of a large number of inflammatory cells. In the formation and progression of the inflammatory lesion, both T lymphocytes that cross the blood-brain barrier and act on the cerebral parenchyma, such as B lymphocytes, contribute to the demyelination process through the secretion of antibodies...
Multiple Sclerosis (MS) is a demyelinating and neurodegenerative chronic inflammatory disease that selectively affects the central nervous system (CNS). Mainly it develops in young adults (25-30 years) and is characterized by the appearance of focal lesions in the white matter (plaques). In these lesions demyelination and axonal destruction can be observed with infiltration of a large number of inflammatory cells. In the formation and progression of the inflammatory lesion, both T lymphocytes that cross the blood-brain barrier and act on the cerebral parenchyma, such as B lymphocytes, contribute to the demyelination process through the secretion of antibodies...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Inmunología, Oftalmología y Otorrinolaringología, leída el 05-02-2018