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Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil

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dc.contributor.authorSevillano Fernández, David
dc.contributor.authorAguilar, Lorenzo
dc.contributor.authorAlou Cervera, Luis
dc.contributor.authorGimenez, María José
dc.contributor.authorTorrico, Martha
dc.contributor.authorGonzález Hidalgo, Natalia
dc.contributor.authorCafini, Fabio
dc.contributor.authorRelaño, María Teresa
dc.contributor.authorCoronel, Pilar
dc.contributor.authorPrieto Prieto, José
dc.date.accessioned2024-07-24T12:51:01Z
dc.date.available2024-07-24T12:51:01Z
dc.date.issued2008-03
dc.description.abstractActivity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipTedec-Meiji Farma S.A.
dc.description.statuspub
dc.identifier.citationSevillano D, Aguilar L, Alou L, Giménez M, Torrico M, González N, Cafini F, Relaño M, Coronel P, Prieto J 2008. Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil. Antimicrob Agents Chemother 52:. https://doi.org/10.1128/aac.01247-07
dc.identifier.doi10.1128/aac.01247-07
dc.identifier.essn1098-6596
dc.identifier.issn0066-4804
dc.identifier.officialurlhttps://doi.org/10.1128/aac.01247-07
dc.identifier.relatedurlhttps://journals.asm.org/doi/10.1128/aac.01247-07
dc.identifier.urihttps://hdl.handle.net/20.500.14352/107129
dc.issue.number3
dc.journal.titleAntimicrobial Agents and Chemotherapy
dc.language.isoeng
dc.page.final1186
dc.page.initial1184
dc.publisherAmerican Society for Microbiology
dc.rights.accessRightsrestricted access
dc.subject.cdu611.02
dc.subject.ucmMicrobiología médica
dc.subject.unesco2414 Microbiología
dc.titleUrine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number52
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery518c916a-df78-48cc-9bf7-6a2aaca7d6a2

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