Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14

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dc.contributor.authorRodríguez, Ana Eugenia
dc.contributor.authorHernández, Jose Ángel
dc.contributor.authorBenito, Rocío
dc.contributor.authorGutiérrez, Norma
dc.contributor.authorGarcía, Juan Luis
dc.contributor.authorHernández Sánchez, María
dc.contributor.authorRisueño, Alberto
dc.contributor.authorSarasquete, M. Eugenia
dc.contributor.authorFermiñán, Encarna
dc.contributor.authorFisac, Rosa
dc.contributor.authorGarcía de Coca, Alfonso
dc.contributor.authorMartín-Núñez, Guillermo
dc.contributor.authorHeras, Natalia de las
dc.contributor.authorRecio, Isabel
dc.contributor.authorGutiérrez, Oliver
dc.contributor.authorRivas, Javier De Las
dc.contributor.authorGonzález, Marcos
dc.contributor.authorHernández-Rivas, Jesús
dc.date.accessioned2024-01-16T11:58:14Z
dc.date.available2024-01-16T11:58:14Z
dc.date.issued2012
dc.description.abstractBackground Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (<80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Sanidad (España)
dc.description.sponsorshipCaja de Burgos
dc.description.sponsorshipJunta de Castilla y León
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipMinisterio de Ciencias e Innovación (España)
dc.description.sponsorshipUniversidad de Salamanca
dc.description.statuspub
dc.identifier.citationRodríguez AE, Hernández JÁ, Benito R, Gutiérrez NC, García JL, Hernández-Sánchez M, et al. Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14. PLoS ONE 2012;7:e48485. https://doi.org/10.1371/journal.pone.0048485.
dc.identifier.doi10.1371/journal.pone.0048485
dc.identifier.essn1932-6203
dc.identifier.officialurlhttps://doi.org/10.1371/journal.pone.0048485
dc.identifier.relatedurlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048485
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93345
dc.issue.number11
dc.journal.titlePlos One
dc.language.isoeng
dc.page.initiale48485
dc.publisherPublic Library of Science
dc.relation.projectIDinfo:eu-repo/grantAgreement/02/1041
dc.relation.projectIDinfo:eu-repo/grantAgreement/FIS 09/01543
dc.relation.projectIDinfo:eu-repo/grantAgreement/106/A/06
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616-006.04-085
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleMolecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number7
dspace.entity.typePublication
relation.isAuthorOfPublicationa4a145b6-73fb-465c-9c1b-969175cd85bd
relation.isAuthorOfPublication.latestForDiscoverya4a145b6-73fb-465c-9c1b-969175cd85bd
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