Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians

Simple item page
dc.contributor.authorFernández-Loras, Andrés
dc.contributor.authorFernández-Beaskoetxea, Saioa
dc.contributor.authorArriero Higueras, Elena
dc.contributor.authorFisher, Matthew C.
dc.contributor.authorBosch López, Jaime Alfonso
dc.date.accessioned2023-06-17T22:19:54Z
dc.date.available2023-06-17T22:19:54Z
dc.date.issued2017-12
dc.description.abstractFungal pathogens have evolved a broad suite of strategies aiming at evading the host immune response. Amphibians are globally infected by the panzootic chytrid fungus Batrachochytrium dendrobatidis (Bd) and, while robust innate immune defences have been characterised, there is little evidence for the existence of effective adaptive immunity. We determine the immune response of the common midwife toad following challenge by Bd as larvae. Immune function was described for both the cell-mediated and antibody-mediated immune responses following infectious challenge as larval amphibians. While there were no significant differences in the ratio of neutrophils/lymphocytes between infected and uninfected individuals, early exposure of tadpoles to Bd significantly dampened the levels of circulating immunoglobulins (IgM and IgY) in the serum of juveniles after metamorphosis. Our results show that Bd immunosuppresses amphibians when infection occurs as larvae with potentially broad effects on the remodelling of immunity during metamorphosis.
dc.description.departmentDepto. de Biodiversidad, Ecología y Evolución
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipFundación General CSIC (España)-Banco de Santander
dc.description.sponsorshipLeverhulme Trust(UK)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/46439
dc.identifier.doi10.1007/s10344-017-1161-y
dc.identifier.issn1612-4642, ESSN: 1439-0574
dc.identifier.officialurlhttps://link.springer.com/article/10.1007/s10344-017-1161-y
dc.identifier.urihttps://hdl.handle.net/20.500.14352/18382
dc.issue.number6
dc.journal.titleEuropean Journal of Wildlife Research
dc.language.isoeng
dc.page.final5
dc.page.initial1
dc.publisherSpringer
dc.relation.projectIDRPG 2014 273
dc.rights.accessRightsrestricted access
dc.subject.cdu597.6
dc.subject.cdu591.1
dc.subject.keywordBatrachochytrium dendrobatidis
dc.subject.keywordImmune response
dc.subject.keywordImmunosuppression
dc.subject.keywordEmerging infectious disease
dc.subject.keywordEarly exposure
dc.subject.ucmAnfibios
dc.subject.ucmFisiología animal (Biología)
dc.subject.unesco2401.17 Invertebrados
dc.subject.unesco2401.13 Fisiología Animal
dc.titleEarly exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians
dc.typejournal article
dc.volume.number63
dspace.entity.typePublication
relation.isAuthorOfPublication37b83c4c-0820-45d3-8b5f-119b7bbefe82
relation.isAuthorOfPublication2fef7179-4d43-4356-b99a-8c78cae4162a
relation.isAuthorOfPublication.latestForDiscovery37b83c4c-0820-45d3-8b5f-119b7bbefe82
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Fernándes-Loras, A. et al. Early exposure Batrachochytrium.pdf
Size:
455.17 KB
Format:
Adobe Portable Document Format
Download
Collections
Artículos