Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm

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dc.contributor.authorHerrera González, David
dc.contributor.authorAlonso Álvarez, Bettina María
dc.contributor.authorLeón, Rubén
dc.contributor.authorRoldán, Silvia
dc.contributor.authorSanz Alonso, Mariano
dc.date.accessioned2024-02-02T15:06:33Z
dc.date.available2024-02-02T15:06:33Z
dc.date.issued2008
dc.description.abstractObjectives: The aim was to answer three relevant questions: can systemic antimicrobials be efficacious if the biofilm is not disrupted? Can the type of debridement of the subgingival biofilm impact upon the clinical outcomes of the adjunctive antimicrobial therapy? Is the efficacy of the adjunctive systemic antimicrobial therapy dependent on the quality of the debridement of the subgingival biofilm and the sequence debridement–antibiotic usage? Material and Methods: Relevant papers were searched, critically analysed and their data were extracted. Results: For the first question, studies assessing susceptibility of bacteria in biofilms, and clinical studies evaluating systemic antimicrobials as monotherapy, were reviewed. For the second question, clinical studies comparing systemic antimicrobials as adjuncts to non-surgical debridement or to periodontal surgery and clinical trials using systemic antibiotics with periodontal surgery were evaluated. For the third question, a previous systematic review was updated. Conclusion: If systemic antimicrobials are indicated in periodontal therapy, they should be adjunctive to mechanical debridement. There is not enough evidence to support their use with periodontal surgery. Indirect evidence suggests that antibiotic intake should start on the day of debridement completion, debridement should be completed within a short time (preferably <1 week) and with an adequate quality, to optimize the results.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationHerrera D, Alonso B, León R, Roldán S, Sanz M. Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. J Clin Periodontol. 2008 Sep;35(8 Suppl):45-66.
dc.identifier.doi10.1111/j.1600-051X.2008.01260.x
dc.identifier.essn1600-051X
dc.identifier.issn0303-6979
dc.identifier.officialurlhttps://doi.org/10.1111/j.1600-051X.2008.01260.x
dc.identifier.pmid18724841
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2008.01260.x
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98383
dc.issue.number(8 suppl.)
dc.journal.titleJournal of Clinical Periodontology
dc.language.isoeng
dc.page.final66
dc.page.initial45
dc.publisherWiley
dc.rights.accessRightsrestricted access
dc.subject.cdu616.314.17-008.1
dc.subject.cdu615.2
dc.subject.keywordBiofilm
dc.subject.keywordNon-surgical
dc.subject.keywordPeriodontitis
dc.subject.keywordSurgical therapy
dc.subject.keywordSystemic antimicrobials
dc.subject.ucmPeriodoncia
dc.subject.ucmMedicamentos
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.subject.unesco3209.03 Evaluación de Medicamentos
dc.titleAntimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number35
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery92a06fae-e947-48dc-b945-32283225e711
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