Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death

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dc.contributor.authorMolina Martín, María
dc.contributor.authorGuerrero Ramos, Félix
dc.contributor.authorFernández Ruiz, Mario
dc.contributor.authorGonzález Monte, Esther
dc.contributor.authorCabrera, Jimena
dc.contributor.authorMorales Ruiz, Enrique
dc.contributor.authorGutiérrez Martínez, Eduardo
dc.contributor.authorHernández Martínez, Eduardo Rafael
dc.contributor.authorPolanco, Natalia
dc.contributor.authorHernández Vicente, Ana
dc.contributor.authorPraga Terente, Manuel
dc.contributor.authorRodríguez Antolín, Alfredo
dc.contributor.authorPamplona Casamayor, Manuel
dc.contributor.authorRosa, Federico de la
dc.contributor.authorCavero, Teresa
dc.contributor.authorChico, Mario
dc.contributor.authorVillar, Alicia
dc.contributor.authorJusto Alonso, Iago
dc.contributor.authorAndrés Belmonte, Amado
dc.date.accessioned2024-02-05T11:27:29Z
dc.date.available2024-02-05T11:27:29Z
dc.date.issued2018-06-27
dc.description.abstractUncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplant (KT) with short-term outcomes similar to those obtained from donation after brain death (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year outcomes between 237 KT recipients from uDCD donors maintained by normothermic extracorporeal membrane oxygenation (nECMO) and 237 patients undergoing KT from standard criteria DBD donors during the same period at our institution. We further analyzed risk factors for death-censored graft survival in the uDCD group. Delayed graft function (DGF) was more common in the uDCD group (73.4% vs 46.4%; P < .01), although glomerular filtration rates at the end of follow-up were similar in the 2 groups. uDCD and DBD groups had similar rates for 10-year death-censored graft (82.1% vs 80.4%; P = .623) and recipient survival (86.2% vs 87.6%; P = .454). Donor age >50 years was associated with graft loss in the uDCD group (hazard ratio: 1.91; P = .058), whereas the occurrence of DGF showed no significant effect. uDCD KT under nECMO support resulted in similar graft function and long-term outcomes compared with KT from standard criteria DBD donors. Increased donor age could negatively affect graft survival after uDCD donation.
dc.description.departmentDepto. de Cirugía
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMolina M, Guerrero-Ramos F, Fernández-Ruiz M, González E, Cabrera J, Morales E, Gutierrez E, Hernández E, Polanco N, Hernández A, Praga M, Rodriguez-Antolín A, Pamplona M, de la Rosa F, Cavero T, Chico M, Villar A, Justo I, Andrés A. Kidney transplant from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death. Am J Transplant. 2019 Feb;19(2):434-447. doi: 10.1111/ajt.14991
dc.identifier.doi10.1111/ajt.14991
dc.identifier.issn1600-6135
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S160061352208947X?via%3Dihub
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/29947163/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98838
dc.issue.number2
dc.journal.titleAmerican Journal of Transplantation
dc.language.isoeng
dc.page.final447
dc.page.initial434
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu617
dc.subject.keywordClinical research / practice
dc.subject.keywordDonors and donation: donation after brain death (DBD)
dc.subject.keywordDonors and donation: donation after circulatory death (DCD)
dc.subject.keywordExtracorporeal membrane oxygenation (ECMO)
dc.subject.keywordGraft survival
dc.subject.keywordKidney disease
dc.subject.keywordKidney transplantation / nephrology
dc.subject.ucmCirugía
dc.subject.unesco3213 Cirugía
dc.titleKidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number19
dspace.entity.typePublication
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