Typhim vi immunization assists to discriminate primary antibody responses in hematological malignancies

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dc.contributor.authorOchoa-Grullón, J.
dc.contributor.authorOrte, C.
dc.contributor.authorRodríguez de la Peña, A.
dc.contributor.authorGuevara-Hoyer, K.
dc.contributor.authorCordero Torres, G.
dc.contributor.authorSerrano-García, I.
dc.contributor.authorPérez de Diego, R.
dc.contributor.authorSánchez-Ramón, S.
dc.contributor.authorFernández Arquero, Miguel
dc.contributor.authorRecio Hoyas, María José
dc.date.accessioned2024-01-12T15:11:36Z
dc.date.available2024-01-12T15:11:36Z
dc.date.issued2020
dc.description.abstractAssessment of specific antibody (Ab) production to polysaccharide antigens is clinically relevant, identifying patients at risk for infection by encapsulated bacteria and thus enabling a more rigorous selection of patients that can benefit of immunoglobulin replacement therapy. Classically, the gold-standard test is the measurement of antibody production to pure polysaccharide pneumococcal (PPV) immunization. Several factors, including introduction of conjugate vaccination schedule, serotyping analysis, high baseline Ab levels, have hindered the evaluation of polysaccharide antigens. This is even more difficult in secondary immunodeficiencies (SID), where patients can show secondary responses despite lack of primary antibody responses and present with recurrent or severe infections. Assessment of specific Ab production to pure Salmonella typhi Vi polysaccharide (TV) immunization has been proposed as a complementary test to PPV, given its low seroprevalence. To set the optimal cut-off value for PPV and TV response in SID, we tested different biostatistical methodologies, including ROC analysis, Youden index, Union index and Closest-topleft in a cohort of 42 SID patients and 24 healthy controls. The statistically chosen cut-offs value pre-post TV Ab ratio was ≥5, (sensitivity of 90%, specificity of 100%) and a postvaccination TV concentration of 28.5 U/mL (sensitivity of 90%, specificity of 95%), showing relevant clinical correlate.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationOchoa-Grullón J, Orte C, Rodríguez de la Peña A, Guevara-Hoyer K, Cordero Torres G, Fernández-Arquero M, Serrano-García I, Recio MJ, Pérez de Diego R, Sánchez-Ramón S. MethodsX. 2020 May 29;7:100936.
dc.identifier.doi10.1016/j.mex.2020.100936
dc.identifier.issn2215-0161
dc.identifier.officialurlhttps://www.sciencedirect.com/journal/methodsx
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92850
dc.journal.titleMethodsX
dc.language.isoeng
dc.publisherELSEVIER
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu612.017
dc.subject.keywordHematological Malignancies
dc.subject.keywordPneumo 23
dc.subject.keywordPrimary responses
dc.subject.keywordROC curve
dc.subject.keywordTyphim Vi
dc.subject.keywordUnion index
dc.subject.keywordSpecific polysaccharide Ab response.
dc.subject.keywordYouden index
dc.subject.keywordSecondary responses
dc.subject.ucmInmunología
dc.subject.unesco2412 Inmunología
dc.titleTyphim vi immunization assists to discriminate primary antibody responses in hematological malignancies
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number7
dspace.entity.typePublication
relation.isAuthorOfPublication9ee6ea4a-b0a0-468e-9b6f-21156771b804
relation.isAuthorOfPublication436ddd6b-73c0-4f41-9d60-f15490326809
relation.isAuthorOfPublication.latestForDiscovery9ee6ea4a-b0a0-468e-9b6f-21156771b804
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