Evaluación de los efectos hepáticos de la administración de Bisfenol A y Bisfenol F en un modelo experimental murino
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2025
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20/03/2024
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Universidad Complutense de Madrid
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Abstract
El bisfenol A (BPA) es un compuesto fenólico utilizado en la elaboración de plásticos para la protección o el envasado de alimentos. El BPA se considera un disruptor endocrino (DE) que causa daños adversos, incluyendo efectos endocrinos, reproductivos, metabólicos, cardiovasculares e incluso cáncer, por lo que se considera un riesgo para la salud pública. Debido a los riesgos asociados al BPA, su análogo, el bisfenol F (BPF) está sustituyendo al BPA en la fabricación de productos plásticos de base. Los monómeros de BPF, al igual que los del BPA, pueden liberarse en la cadena alimentaria, lo que da lugar a una exposición humana continua a dosis bajas. Dado que los bisfenoles se metabolizan principalmente en el hígado, este órgano es más vulnerable a dosis bajas de bisfenoles que otros...
Bisphenol A (BPA) is a phenolic compound used in plastics elaboration for food protection or packaging. BPA is considered an endocrine disruptor (ED) that causes health problems in humans, including endocrine, reproductive, metabolic, cardiovascular disorders and even cancer, so that it has been considered a risk for public health. Due to the risks associated with BPA, its analogue, bisphenol F (BPF) is replacing BPA in the manufacture of basic plastic products. BPF monomers, like BPA monomers, can be released into the food chain, resulting in continuous low-dose human exposure. Since bisphenols are mainly metabolized in the liver, this organ is more vulnerable to low doses of bisphenols than others...
Bisphenol A (BPA) is a phenolic compound used in plastics elaboration for food protection or packaging. BPA is considered an endocrine disruptor (ED) that causes health problems in humans, including endocrine, reproductive, metabolic, cardiovascular disorders and even cancer, so that it has been considered a risk for public health. Due to the risks associated with BPA, its analogue, bisphenol F (BPF) is replacing BPA in the manufacture of basic plastic products. BPF monomers, like BPA monomers, can be released into the food chain, resulting in continuous low-dose human exposure. Since bisphenols are mainly metabolized in the liver, this organ is more vulnerable to low doses of bisphenols than others...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 20-03-2024