Sevoflurane Prevents Liver Inflammatory Response Induced by Lung Ischemia-Reperfusion

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dc.contributor.authorRancán, Lisa
dc.contributor.authorHuerta Martínez, Luis Javier
dc.contributor.authorCusati, Gabriel
dc.contributor.authorErquicia, Iñaki
dc.contributor.authorIsea, Jesús
dc.contributor.authorParedes Royano, Sergio Damián
dc.contributor.authorGarcía Martín, M. Cruz
dc.contributor.authorGarutti Martínez, Ignacio
dc.contributor.authorSimón Adiego, Carlos María
dc.contributor.authorVara Ameigeiras, Elena María
dc.date.accessioned2024-01-15T17:09:31Z
dc.date.available2024-01-15T17:09:31Z
dc.date.issued2014
dc.description.abstractBackground: Transplants cause ischemia-reperfusion (IR) injury that can affect distant organs. Liver is particularly sensitive to IR injury. The present randomized experimental study was designed to investigate a possible protective effect of sevoflurane against liver inflammatory response to lung IR in a lung upper lobe left autotransplant model. Methods: Two groups (sevoflurane and control) of eight swines each were submitted to upper lobe left lung autotransplant. Hypnotic maintenance was performed with sevoflurane 3% or propofol 8 to 10 mg/kg per hr until pneumonectomy was done; then propofol was used for all animals. Blood and liver samples were taken in four different moments: prepneumonectomy, prereperfusion, 10 min postreperfusion and 30 min postreperfusion to measure levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1, nuclear factor (NF)-κB, C-reactive protein, ferritin and caspase 3. Non-parametric test was used to find statistical meaning. Results: Lung IR markedly increased the expression of TNF-α, IL-1β, MCP-1, NF-κB and caspase activity in control livers compared with basal levels, whereas liver IL-10 expression decreased 10 and 30 min post-reperfusion. Sevoflurane significantly decreased TNF-α, IL-1β, MCP-1, NF-κB liver expression and caspase 3 activity. Sevoflurane also reverted the lung IR-induced decrease in IL-10 expression. Conclusions: The present results indicate that lung IR caused hepatic injury. Sevoflurane attenuated liver injury in a model of upper lobe left lung autotransplant in pigs.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia y Educación (España)
dc.description.statuspub
dc.identifier.citationRancan, Lisa1,5; Huerta, Luis2; Cusati, Gabriel3; Erquicia, Iñaki3; Isea, Jesús2; Paredes, Sergio D.4; García, Cruz1; Garutti, Ignacio3; Simón, Carlos2; Vara, Elena1. Sevoflurane Prevents Liver Inflammatory Response Induced by Lung Ischemia-Reperfusion. Transplantation 98(11):p 1151-1157, December 15, 2014. | DOI: 10.1097/TP.0000000000000408
dc.identifier.doi10.1097/tp.0000000000000408
dc.identifier.issn0041-1337
dc.identifier.officialurlhttps://www.doi.org/10.1097/TP.0000000000000408
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93192
dc.issue.number11
dc.journal.titleTransplantation
dc.language.isoeng
dc.page.final1157
dc.page.initial1151
dc.publisherWolters Kluwer Health, Inc.
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu61
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco2403 Bioquímica
dc.titleSevoflurane Prevents Liver Inflammatory Response Induced by Lung Ischemia-Reperfusion
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number98
dspace.entity.typePublication
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