Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub

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dc.contributor.authorBecerro De Bengoa Vallejo, Ricardo
dc.contributor.authorSevillano Fernández, David
dc.contributor.authorAlou Cervera, Luis
dc.contributor.authorMartín Aragón, Laura
dc.contributor.authorLosa Iglesias, Marta Elena
dc.contributor.authorCollado Yurrita, Luis Rodolfo
dc.contributor.authorLopez Lopez, Daniel
dc.date.accessioned2024-07-12T12:43:30Z
dc.date.available2024-07-12T12:43:30Z
dc.date.issued2018-10
dc.description.abstractBackground: Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy "in vivo. Methods: We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1). We assessed bacterial load after a prewash with soft soap, immediately after application of an antiseptic, and 3 hours after application and wearing of sterile, powder-free gloves. Our procedures followed those specified by European Norm (EN) 12791 for evaluating surgical hand antiseptics and using cotton swab for fingertips and fingernails. Results: Chlorhexidine digluconate 4% and PCMX 3% did not decrease bacterial load on the hands. The bactericidal performances of chlorhexidine digluconate 4% and PCMX 3% did not differ significantly. Chlorhexidine digluconate 4% and PCMX 3% increased bacterial load on the fingertips after participants had worn gloves for 3 hours. Fingernails had greater bacterial loads than skin on the fingertips. Conclusions: Chlorhexidine digluconate 4% and PCMX 3% had similar bactericidal efficacy, but they failed to meet the EN 12791 efficacy standard. Fingernails should be a particular focus of antisepsis in preparation for surgery.The trial was registered at ClinicalTrials.gov (ID: NCT02500758).
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationVallejo RBB, Fernandez DS, Cervera LA, Aragón LM, Iglesias MEL, Yurrita LRC, Lopez DL. Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub: Cross-over trial. Medicine (Baltimore). 2018 Oct;97(42):e12831.
dc.identifier.doi10.1097/md.0000000000012831
dc.identifier.essn1536-5964
dc.identifier.issn0025-7974
dc.identifier.officialurlhttp://dx.doi.org/10.1097/MD.0000000000012831
dc.identifier.pmid30334981
dc.identifier.relatedurlhttps://journals.lww.com/md-journal/fulltext/2018/10190/effectiveness_of_surgical_hand_antisepsis_using.44.aspx
dc.identifier.urihttps://hdl.handle.net/20.500.14352/106043
dc.issue.number42 (e12831)
dc.journal.titleMedicine (Baltimore) .
dc.language.isoeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.cdu579
dc.subject.keywordAntisepsis
dc.subject.keywordRandomized controlled trial
dc.subject.keywordSurgical site infection
dc.subject.ucmMicrobiología médica
dc.subject.unesco2414 Microbiología
dc.titleEffectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number97
dspace.entity.typePublication
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relation.isAuthorOfPublication518c916a-df78-48cc-9bf7-6a2aaca7d6a2
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