Oxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension

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dc.contributor.authorMorales Cano, Daniel
dc.contributor.authorBarreira, Bianca
dc.contributor.authorDe Olaiz Navarro, Beatriz
dc.contributor.authorCallejo Arranz, María
dc.contributor.authorMondejar Parreño, Gema
dc.contributor.authorEsquivel Ruiz, Sergio Antonio
dc.contributor.authorLorente, José Ángel
dc.contributor.authorMoreno Gutiérrez, Laura
dc.contributor.authorBarberá, Joan Albert
dc.contributor.authorCogolludo Torralba, Ángel Luis
dc.contributor.authorPérez Vizcaíno, Francisco
dc.date.accessioned2024-02-02T11:44:05Z
dc.date.available2024-02-02T11:44:05Z
dc.date.issued2021-01-21
dc.description.abstractCurrent approved therapies for pulmonary hypertension (PH) aim to restore the balance between endothelial mediators in the pulmonary circulation. These drugs may exert vasodilator effects on poorly oxygenated vessels. This may lead to the derivation of blood perfusion towards low ventilated alveoli, i.e., producing ventilation-perfusion mismatch, with detrimental effects on gas exchange. The aim of this study is to analyze the oxygen-sensitivity in vitro of 25 drugs currently used or potentially useful for PH. Additionally, the study analyses the effectiveness of these vasodilators in the pulmonary vs the systemic vessels. Vasodilator responses were recorded in pulmonary arteries (PA) and mesenteric arteries (MA) from rats and in human PA in a wire myograph under different oxygen concentrations. None of the studied drugs showed oxygen selectivity, being equally or more effective as vasodilators under conditions of low oxygen as compared to high oxygen levels. The drugs studied showed low pulmonary selectivity, being equally or more effective as vasodilators in systemic than in PA. A similar behavior was observed for the members within each drug family. In conclusion, none of the drugs showed optimal vasodilator profile, which may limit their therapeutic efficacy in PH.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipUnión Europea
dc.description.sponsorshipFundación contra la Hipertensión Pulmonar
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationMorales-Cano D, Barreira B, Navarro BO, Callejo M, Mondejar-Parreño G, Esquivel-Ruiz S, Lorente JA, Moreno L, Barberá JA, Cogolludo Á, Perez-Vizcaino F. Oxygen-sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension. Antioxidants (Basel). 2021 Jan 21;10(2):155. doi: 10.3390/antiox10020155
dc.identifier.doi10.3390/antiox10020155
dc.identifier.issn2076-3921
dc.identifier.officialurlhttps://www.mdpi.com/2076-3921/10/2/155
dc.identifier.pmid33494520
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33494520/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98216
dc.issue.number2
dc.journal.titleAntioxidants
dc.language.isoeng
dc.page.final14
dc.page.initial1
dc.publisherMDPI
dc.relation.projectIDSAF2011-28150
dc.relation.projectIDSAF2016-77222
dc.relation.projectIDPID2019-107363RB-I00
dc.relation.projectIDPI15/01100
dc.relation.projectIDFIS PI14/01733
dc.relation.projectIDFEDER
dc.relation.projectIDBES-2012-051904
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu615.01/.03
dc.subject.keywordPulmonary hypertension
dc.subject.keywordVascular
dc.subject.keywordVasodilator
dc.subject.keywordOxygen-sensing
dc.subject.ucmFarmacología (Medicina)
dc.subject.unesco2411.03 Fisiología Cardiovascular
dc.titleOxygen-Sensitivity and Pulmonary Selectivity of Vasodilators as Potential Drugs for Pulmonary Hypertension
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
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