Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial.
dc.contributor.author | Sánchez Pérez, Silvia Nerea | |
dc.contributor.author | Fierravanti, Ludovica | |
dc.contributor.author | Nuñez, Javier | |
dc.contributor.author | Vignoletti, Fabio | |
dc.contributor.author | González Zamora, María | |
dc.contributor.author | Santamaria, Silvia | |
dc.contributor.author | Suárez Sancho, Susana | |
dc.contributor.author | Fernández Santos, Maria Eugenia | |
dc.contributor.author | Figuero Ruiz, Elena | |
dc.contributor.author | Herrera González, David | |
dc.contributor.author | Sanz Alonso, Mariano | |
dc.date.accessioned | 2024-02-09T12:12:50Z | |
dc.date.available | 2024-02-09T12:12:50Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Aim: To evaluate the safety and efficacy of autologous periodontal ligament-derived mesenchymal stem cells (PDL-MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra-bony periodontal defects. Material and methods: This quasi-randomized controlled pilot phase II clinical trial included patients requiring a tooth extraction and presence of one intra-bony lesion (1-2 walls). Patients were allocated to either the experimental (XBS + 10 × 106 PDL-MSCs/100 mg) or the control group (XBS). Clinical and radiographical parameters were recorded at baseline, 6, 9 and 12 months. The presence of adverse events was also evaluated. Chi-square, Student's t test, Mann-Whitney U, repeated-measures ANOVA and regression models were used. Results: Twenty patients were included. No serious adverse events were reported. Patients in the experimental group (n = 9) showed greater clinical attachment level (CAL) gain (1.44, standard deviation [SD] = 1.87) and probing pocket depth (PPD) reduction (2.33, SD = 1.32) than the control group (n = 10; CAL gain = 0.88, SD = 1.68, and PPD reduction = 2.10, SD = 2.46), without statistically significant differences. Conclusion: The application of PDL-MSCs to XBS for the treatment of one- to two-wall intra-bony lesions was safe and resulted in low postoperative morbidity and appropriate healing, although its additional benefit, when compared with the XBS alone, was not demonstrated. | en |
dc.description.department | Depto. de Especialidades Clínicas Odontológicas | |
dc.description.faculty | Fac. de Odontología | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Ministerio de Sanidad (España) | |
dc.description.status | pub | |
dc.identifier.citation | Sánchez N, Fierravanti L, Núñez J, Vignoletti F, González-Zamora M, Santamaría S, Suárez-Sancho S, Fernández-Santos ME, Figuero E, Herrera D, García-Sanz JA, Sanz M. Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial. J Clin Periodontol. 2020 Nov;47(11):1391-1402. doi: 10.1111/jcpe.13368. PMID: 32946590. | |
dc.identifier.doi | 10.1111/jcpe.13368. | |
dc.identifier.issn | 1600-051X | |
dc.identifier.officialurl | https://doi.org/10.1111/jcpe.13368 | |
dc.identifier.pmid | 32946590 | |
dc.identifier.relatedurl | https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13368 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/100900 | |
dc.issue.number | 11 | |
dc.journal.title | Journal of Clinical Periodontoly | |
dc.language.iso | eng | |
dc.page.final | 1402 | |
dc.page.initial | 1391 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MISAN//EC10-095 | |
dc.rights.accessRights | restricted access | |
dc.subject.cdu | 616.314.17-008.1 | |
dc.subject.keyword | Cell therapy | |
dc.subject.keyword | Mesenchymal stem cells | |
dc.subject.keyword | Periodontal ligament | |
dc.subject.keyword | Periodontal regeneration | |
dc.subject.keyword | Tissue engineering. | |
dc.subject.ucm | Odontología (Odontología) | |
dc.subject.ucm | Periodoncia | |
dc.subject.unesco | 32 Ciencias Médicas | |
dc.title | Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial. | en |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 47 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | cecf7e57-4ca6-4690-8243-936a09ddc9e5 | |
relation.isAuthorOfPublication | 780965c6-ea4d-4bf1-bbda-99914490ba50 | |
relation.isAuthorOfPublication | 92a06fae-e947-48dc-b945-32283225e711 | |
relation.isAuthorOfPublication | 64cb103c-84c2-43c3-a4fc-60b1e598007d | |
relation.isAuthorOfPublication.latestForDiscovery | cecf7e57-4ca6-4690-8243-936a09ddc9e5 |
Download
Original bundle
1 - 1 of 1