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Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial.

dc.contributor.authorSánchez Pérez, Silvia Nerea
dc.contributor.authorFierravanti, Ludovica
dc.contributor.authorNuñez, Javier
dc.contributor.authorVignoletti, Fabio
dc.contributor.authorGonzález Zamora, María
dc.contributor.authorSantamaria, Silvia
dc.contributor.authorSuárez Sancho, Susana
dc.contributor.authorFernández Santos, Maria Eugenia
dc.contributor.authorFiguero Ruiz, Elena
dc.contributor.authorHerrera González, David
dc.contributor.authorSanz Alonso, Mariano
dc.date.accessioned2024-02-09T12:12:50Z
dc.date.available2024-02-09T12:12:50Z
dc.date.issued2020
dc.description.abstractAim: To evaluate the safety and efficacy of autologous periodontal ligament-derived mesenchymal stem cells (PDL-MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra-bony periodontal defects. Material and methods: This quasi-randomized controlled pilot phase II clinical trial included patients requiring a tooth extraction and presence of one intra-bony lesion (1-2 walls). Patients were allocated to either the experimental (XBS + 10 × 106 PDL-MSCs/100 mg) or the control group (XBS). Clinical and radiographical parameters were recorded at baseline, 6, 9 and 12 months. The presence of adverse events was also evaluated. Chi-square, Student's t test, Mann-Whitney U, repeated-measures ANOVA and regression models were used. Results: Twenty patients were included. No serious adverse events were reported. Patients in the experimental group (n = 9) showed greater clinical attachment level (CAL) gain (1.44, standard deviation [SD] = 1.87) and probing pocket depth (PPD) reduction (2.33, SD = 1.32) than the control group (n = 10; CAL gain = 0.88, SD = 1.68, and PPD reduction = 2.10, SD = 2.46), without statistically significant differences. Conclusion: The application of PDL-MSCs to XBS for the treatment of one- to two-wall intra-bony lesions was safe and resulted in low postoperative morbidity and appropriate healing, although its additional benefit, when compared with the XBS alone, was not demonstrated.en
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Sanidad (España)
dc.description.statuspub
dc.identifier.citationSánchez N, Fierravanti L, Núñez J, Vignoletti F, González-Zamora M, Santamaría S, Suárez-Sancho S, Fernández-Santos ME, Figuero E, Herrera D, García-Sanz JA, Sanz M. Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial. J Clin Periodontol. 2020 Nov;47(11):1391-1402. doi: 10.1111/jcpe.13368. PMID: 32946590.
dc.identifier.doi10.1111/jcpe.13368.
dc.identifier.issn1600-051X
dc.identifier.officialurlhttps://doi.org/10.1111/jcpe.13368
dc.identifier.pmid32946590
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/10.1111/jcpe.13368
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100900
dc.issue.number11
dc.journal.titleJournal of Clinical Periodontoly
dc.language.isoeng
dc.page.final1402
dc.page.initial1391
dc.relation.projectIDinfo:eu-repo/grantAgreement/MISAN//EC10-095
dc.rights.accessRightsrestricted access
dc.subject.cdu616.314.17-008.1
dc.subject.keywordCell therapy
dc.subject.keywordMesenchymal stem cells
dc.subject.keywordPeriodontal ligament
dc.subject.keywordPeriodontal regeneration
dc.subject.keywordTissue engineering.
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmPeriodoncia
dc.subject.unesco32 Ciencias Médicas
dc.titlePeriodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial.en
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number47
dspace.entity.typePublication
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relation.isAuthorOfPublication780965c6-ea4d-4bf1-bbda-99914490ba50
relation.isAuthorOfPublication92a06fae-e947-48dc-b945-32283225e711
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relation.isAuthorOfPublication.latestForDiscoverycecf7e57-4ca6-4690-8243-936a09ddc9e5

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