LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later

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dc.contributor.authorBetancor, Diana
dc.contributor.authorGomez Lopez, Alicia
dc.contributor.authorVillalobos Vilda, Carlos
dc.contributor.authorNuñez Borque, Emilio
dc.contributor.authorFernández Bravo, Sergio
dc.contributor.authorDe las Heras Gozalo, Manuel
dc.contributor.authorPastor Vargas, Carlos
dc.contributor.authorEsteban, Vanesa
dc.contributor.authorCuesta Herranz, Javier
dc.date.accessioned2023-06-17T08:25:09Z
dc.date.available2023-06-17T08:25:09Z
dc.date.issued2021-06-24
dc.description.abstractIntroduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly Rosaceae/Prunoideae fruits and nuts followed by vegetables, Rosacea/Pomoideae fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to Rosaceae/Prunoideae fruits, two to Rosaceae/Prunoideae fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly Rosaceae-Prunoideae fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.departmentDepto. de Medicina
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Medicina)
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/FEDER
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/71658
dc.identifier.doi10.3390/nu13072165
dc.identifier.issn2072-6643
dc.identifier.officialurlhttps://doi.org/10.3390/nu13072165
dc.identifier.relatedurlhttps://www.mdpi.com/2072-6643/13/7/2165
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7045
dc.issue.number7
dc.journal.titleNutrients
dc.language.isoeng
dc.page.initial2165
dc.publisherMPDI
dc.relation.projectIDARADyAL RD16/0006/0013 and PI18/00348
dc.relation.projectIDFOODAL-CM (P2018/BAAA-4574)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordnsLTP
dc.subject.keywordplant-food allergy
dc.subject.keywordPru p 3
dc.subject.keywordpeach
dc.subject.keywordnut
dc.subject.keywordRosaceae fruit
dc.subject.keywordISAC
dc.subject.ucmAlergología
dc.subject.ucmNutrición
dc.subject.ucmDietética
dc.subject.unesco3207.01 Alergias
dc.subject.unesco3206 Ciencias de la Nutrición
dc.titleLTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later
dc.typejournal article
dc.volume.number13
dspace.entity.typePublication
relation.isAuthorOfPublication25af78c7-0077-4891-a14e-bcd8e51fe408
relation.isAuthorOfPublication.latestForDiscovery25af78c7-0077-4891-a14e-bcd8e51fe408
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