Functional Connectivity Hypersynchronization in Relatives of Alzheimer’s Disease Patients: An Early E/I Balance Dysfunction?

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dc.contributor.authorRamírez Toraño, Federico
dc.contributor.authorBruña Fernández, Ricardo
dc.contributor.authorDe Frutos Lucas, Jaisalmer
dc.contributor.authorRodríguez Rojo, Inmaculada Concepción
dc.contributor.authorMarcos de Pedro, Silvia
dc.contributor.authorDelgado Losada, María Luisa
dc.contributor.authorGómez Ruiz, N
dc.contributor.authorBarabash Bustelo, Ana
dc.contributor.authorMarcos Dolado, Alberto
dc.contributor.authorLópez Higes, Ramón
dc.contributor.authorMaestu Unturbe, Fernando
dc.date.accessioned2024-02-08T11:45:41Z
dc.date.available2024-02-08T11:45:41Z
dc.date.issued2020-10-27
dc.description.abstractAlzheimer’s disease (AD) studies on animal models, and humans showed a tendency of the brain tissue to become hyperexcitable and hypersynchronized, causing neurodegeneration. However, we know little about either the onset of this phenomenon or its early effects on functional brain networks. We studied functional connectivity (FC) on 127 participants (92 middle-age relatives of AD patients and 35 age-matched nonrelatives) using magnetoencephalography. FC was estimated in the alpha band in areas known both for early amyloid accumulation and disrupted FC in MCI converters to AD. We found a frontoparietal network (anterior cingulate cortex, dorsal frontal, and precuneus) where relatives of AD patients showed hypersynchronization in high alpha (not modulated by APOE-ε4 genotype) in comparison to age-matched nonrelatives. These results represent the first evidence of neurophysiological events causing early network disruption in humans, opening a new perspective for intervention on the excitation/inhibition unbalance.
dc.description.departmentDepto. de Psicología Experimental, Procesos Cognitivos y Logopedia
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Psicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipFundación La Caixa
dc.description.statuspub
dc.identifier.citationRamírez-Toraño F, Bruña R, de Frutos-Lucas J, Rodríguez-Rojo IC, Marcos de Pedro S, Delgado-Losada ML, Gómez-Ruiz N, Barabash A, Marcos A, López Higes R, Maestú F. Functional Connectivity Hypersynchronization in Relatives of Alzheimer's Disease Patients: An Early E/I Balance Dysfunction? Cereb Cortex. 2021 Jan 5;31(2):1201-1210. doi: 10.1093/cercor/bhaa286
dc.identifier.doi10.1093/cercor/bhaa286
dc.identifier.issn1460-2199
dc.identifier.officialurlhttps://academic.oup.com/cercor/article/31/2/1201/5941596
dc.identifier.pmid33108468
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33108468/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100361
dc.issue.number2
dc.journal.titleCerebral Cortex
dc.language.isoeng
dc.page.final1210
dc.page.initial1201
dc.publisherOxford University Press
dc.relation.projectIDPSI2015-68793-C3-1-R
dc.relation.projectIDPSI2015-68793-C3-2-R
dc.relation.projectIDPSI2015-68793-C3-3-R
dc.relation.projectIDRTI2018-098762-B-C31
dc.relation.projectIDBES-2016-076869
dc.relation.projectIDB2017/BMD-3760
dc.rights.accessRightsrestricted access
dc.subject.cdu612.8
dc.subject.keywordEarly detection
dc.subject.keywordExcitation/inhibition unbalance
dc.subject.keywordMagnetoencephalography
dc.subject.keywordNetwork disruption
dc.subject.keywordRelatives of Alzheimer’s disease patients
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco2490 Neurociencias
dc.titleFunctional Connectivity Hypersynchronization in Relatives of Alzheimer’s Disease Patients: An Early E/I Balance Dysfunction?
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number31
dspace.entity.typePublication
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