Evaluation of new chlorhexidineand cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study

Simple item page
dc.contributor.authorGarcía-Gargallo, M
dc.contributor.authorZurlohe, Martina
dc.contributor.authorMontero Solís, Eduardo
dc.contributor.authorAlonso Álvarez, Bettina María
dc.contributor.authorSerrano, Jorge
dc.contributor.authorSanz Alonso, Mariano
dc.contributor.authorHerrera González, David
dc.date.accessioned2024-02-02T11:03:53Z
dc.date.available2024-02-02T11:03:53Z
dc.date.issued2017-11
dc.description.abstractObjective: To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested. Methods: A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0.12% CHX and 0.05% CPC); (ii) SRP and test-2 (new formulation: 0.03% CHX and 0.05% CPC); or (iii) SRP and positive control (commercial product: 0.12% CHX and 0.05% CPC). All variables were evaluated at baseline and 1 month after SRP. Quantitative variables were compared by means of anova or Kruskal-Wallis test and qualitative variables by chi-square or McNemar tests. Results: Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (P = 0.016) as test-1 showed less sites with plaque than test-2 (31.15% [standard error-SE 2.21%] versus 49.39% [SE 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (P = 0.022) of Capnocytophaga spp. Conclusions: Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% CHX and 0.05% CPC mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after SRP.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.sponsorshipThis study was supported by Dentaid (Cerdanyola del Vall es, Barcelona, Spain) through a grant to the ETEP Research Group
dc.description.statuspub
dc.identifier.citationGarcía-Gargallo M, Zurlohe M, Montero E, Alonso B, Serrano J, Sanz M, Herrera D. Evaluation of new chlorhexidine- and cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study. Int J Dent Hyg. 2017 Nov;15(4):269-279
dc.identifier.doi10.1111/idh.12254
dc.identifier.essn1601-5037
dc.identifier.issn1601-5029
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/idh.12254
dc.identifier.pmid27762095
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98183
dc.issue.number4
dc.journal.titleInternational Journal of Dental Hygiene
dc.language.isoeng
dc.page.final279
dc.page.initial269
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616.314
dc.subject.cdu616.314.17-008.1
dc.subject.cdu615.07
dc.subject.cdu615.46
dc.subject.keywordAntiseptics
dc.subject.keywordCetylpyridinium chloride
dc.subject.keywordChlorhexidine
dc.subject.keywordDental plaque
dc.subject.keywordMouthrinse
dc.subject.keywordNon-surgical periodontal therapy
dc.subject.keywordScaling and root planing
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmPeriodoncia
dc.subject.ucmAparatos y material odontológicos
dc.subject.ucmMedicamentos
dc.subject.ucmAnálisis clínicos
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.subject.unesco3209.03 Evaluación de Medicamentos
dc.titleEvaluation of new chlorhexidineand cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15
dspace.entity.typePublication
relation.isAuthorOfPublication4ac18e76-5034-4c79-9861-bd8fb6287b0b
relation.isAuthorOfPublication78b5ba10-4d3e-49b3-8180-abad523f6bb3
relation.isAuthorOfPublication64cb103c-84c2-43c3-a4fc-60b1e598007d
relation.isAuthorOfPublication92a06fae-e947-48dc-b945-32283225e711
relation.isAuthorOfPublication.latestForDiscovery4ac18e76-5034-4c79-9861-bd8fb6287b0b
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Evaluation of new chlorhexidine- and cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study
Size:
413.95 KB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos