Mechanisms of immunity to Leishmania major infection in mice: The contribution of DNA vaccines coding for two novel sets of histones (H2A–H2B or H3–H4)

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dc.contributor.authorCarrión Herrero, Francisco Javier
dc.date.accessioned2024-01-18T16:10:42Z
dc.date.available2024-01-18T16:10:42Z
dc.date.issued2011
dc.description.abstractThe immune phenotype conferred by two different sets of histone genes (H2A-H2B or H3-H4) was assessed. BALB/c mice vaccinated with pcDNA3H2AH2B succumbed to progressive cutaneous leishmaniosis (CL), whereas vaccination with pcDNA3H3H4 resulted in partial resistance to Leishmania major challenge associated with the development of mixed T helper 1 (Th1)/Th2-type response and a reduction in parasite-specific Treg cells number at the site of infection. Therefore, the presence of histones H3 and H4 may be considered essential in the development of vaccine strategies against CL based on the Leishmania histones.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Educación y Ciencia (España)
dc.description.statuspub
dc.identifier.citationCarrión J. (2011). Mechanisms of immunity to Leishmania major infection in mice: the contribution of DNA vaccines coding for two novel sets of histones (H2A-H2B or H3-H4). Comparative immunology, microbiology and infectious diseases, 34(5), 381–386. https://doi.org/10.1016/j.cimid.2011.06.002
dc.identifier.doi10.1016/j.cimid.2011.06.002
dc.identifier.issn1878-1667
dc.identifier.officialurlhttps://doi.org/10.1016/j.cimid.2011.06.002
dc.identifier.pmid21840052
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93917
dc.issue.number5
dc.journal.titleComparative Immunology, Microbiology and Infectious Diseases
dc.language.isoeng
dc.page.final386
dc.page.initial381
dc.publisherElsevier
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordHistones
dc.subject.keywordLeishmaniosis
dc.subject.keywordTreg cells
dc.subject.keywordVaccination
dc.subject.ucmVeterinaria
dc.subject.unesco24 Ciencias de la Vida
dc.titleMechanisms of immunity to Leishmania major infection in mice: The contribution of DNA vaccines coding for two novel sets of histones (H2A–H2B or H3–H4)
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number34
dspace.entity.typePublication
relation.isAuthorOfPublication8207c445-ff65-45fc-9070-60fe6e14b5e2
relation.isAuthorOfPublication.latestForDiscovery8207c445-ff65-45fc-9070-60fe6e14b5e2

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