Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

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dc.contributor.authorPolo, Lorena
dc.contributor.authorGómez Cerezo, María Natividad
dc.contributor.authorAznar, Elena
dc.contributor.authorVivancos, José-Luis
dc.contributor.authorSancenón, Félix
dc.contributor.authorArcos Navarrete, Daniel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorMartínez-Máñez, Ramón
dc.date.accessioned2024-01-30T11:06:19Z
dc.date.available2024-01-30T11:06:19Z
dc.date.issued2017-03
dc.description.abstractSilica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and ε-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic (levofloxacin) and an antitumoral drug (doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipGobierno de España
dc.description.sponsorshipGeneralitat Valenciana
dc.description.sponsorshipEuropean Research Council
dc.description.statuspub
dc.identifier.citationPolo L, Gómez-Cerezo N, Aznar E, Vivancos J-L, Sancenón F, Arcos D, et al. Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection. Acta Biomaterialia 2017;50:114–26. https://doi.org/10.1016/j.actbio.2016.12.025.
dc.identifier.doi10.1016/j.actbio.2016.12.025
dc.identifier.issn1742-7061
dc.identifier.officialurlhttps://doi.org/10.1016/j.actbio.2016.12.025
dc.identifier.urihttps://hdl.handle.net/20.500.14352/96416
dc.journal.titleActa Biomaterialia
dc.language.isoeng
dc.page.initial1
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2015-64139-C04-01-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT-2013-43299-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2015-64831-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/CSO2010-11384-E
dc.relation.projectIDinfo:eu-repo/grantAgreement/PROMETEOII/2014/047
dc.rights.accessRightsrestricted access
dc.subject.keywordBiomaterials
dc.subject.keywordControlled release
dc.subject.keywordGated mesoporous bioactive glasses
dc.subject.ucmCiencias
dc.subject.unesco23 Química
dc.titleMolecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
dc.typejournal article
dc.volume.number90
dspace.entity.typePublication
relation.isAuthorOfPublication6e7648cb-126c-471f-8641-6c1b54cb4c72
relation.isAuthorOfPublicationd92c7075-3d31-45ec-a18d-35a5010ee8e1
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery791023b8-2531-44eb-ba01-56e3b7caa0cb
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