Periodontal diseases and depression: A pre‐clinical in vivo study

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dc.contributor.authorMartínez, María
dc.contributor.authorMartín‐Hernández, David
dc.contributor.authorVirto Ruiz, Leire
dc.contributor.authorMac-Dowell Mata, Karina Soledad
dc.contributor.authorLeza Cerro, Juan Carlos
dc.contributor.authorGarcía Bueno, Borja
dc.contributor.authorFiguero Ruiz, Elena
dc.contributor.authorAmbrosio Elejalde, Nagore
dc.contributor.authorHerrera González, David
dc.contributor.authorMontero Solís, Eduardo
dc.contributor.authorGonzález Bris, Álvaro
dc.contributor.authorMarín Cuenda, María José
dc.contributor.authorSanz Martín, Mariano
dc.date.accessioned2024-01-30T19:31:55Z
dc.date.available2024-01-30T19:31:55Z
dc.date.issued2021-02-09
dc.description.abstractAim: To analyse, through a pre-clinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels. Materials and methods: Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during 12 weeks, followed by a 3-week period of Chronic Mild Stress (CMS) induction. Four groups (n = 12 rats/group) were obtained: periodontitis and CMS (P+CMS+); periodontitis without CMS; CMS without periodontitis; and control. Periodontal clinical variables, alveolar bone levels (ABL), depressive-like behaviour, microbial counts and expression of inflammatory mediators in plasma and brain frontal cortex (FC), were measured. ANOVA tests were applied. Results: The highest values for ABL occurred in the P+CMS+ group, which also presented the highest expression of pro-inflammatory mediators (TNF-α, IL-1β and NF-kB) in frontal cortex, related to the lipoprotein APOA1-mediated transport of bacterial lipopolysaccharide to the brain and the detection of F. nucleatum in the brain parenchyma. A dysregulation of the hypothalamic-pituitary-adrenal stress axis, reflected by the increase in plasma corticosterone and glucocorticoid receptor levels in FC, was also found in this group. Conclusions: Neuroinflammation induced by F. nucleatum (through a leaky mouth) might act as the linking mechanism between periodontal diseases and depression.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.sponsorshipSantander-University Complutense of Madrid Projects
dc.description.sponsorshipMINECO-FEDER
dc.description.sponsorshipCIBERSAM
dc.description.statuspub
dc.identifier.citationMartínez M, Martín-Hernández D, Virto L, MacDowell KS, Montero E, González-Bris Á, Marín MJ, Ambrosio N, Herrera D, Leza JC, Sanz M, García-Bueno B, Figuero E. Periodontal diseases and depression: A pre-clinical in vivo study. J Clin Periodontol. 2021 Apr;48(4):503-527. doi: 10.1111/jcpe.13420. PMID: 33432590.
dc.identifier.doi10.1111/jcpe.13420
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/10.1111/jcpe.13420
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33432590/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/96806
dc.issue.number4
dc.journal.titleJournal of Clinical Periodontology
dc.language.isoeng
dc.page.final527
dc.page.initial503
dc.publisherWiley
dc.relation.projectIDPR41/17-20979
dc.relation.projectIDSAF2017-85888-R
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616.89-007
dc.subject.cdu612.8-092.19
dc.subject.cdu612.8
dc.subject.keywordFusobacterium nucleatum
dc.subject.keywordAnimal model
dc.subject.keywordDepression
dc.subject.keywordInflammation
dc.subject.keywordPeriodontitis
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titlePeriodontal diseases and depression: A pre‐clinical in vivo study
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number48
dspace.entity.typePublication
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