Plant Proteases: From Key Enzymes in Germination to Allies for Fighting Human Gluten-Related Disorders

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dc.contributor.authorMartinez, Manuel
dc.contributor.authorGómez-Cabellos, Sara
dc.contributor.authorGiménez, María José
dc.contributor.authorBarro, Francisco
dc.contributor.authorDiaz, Isabel
dc.contributor.authorDíaz Mendoza, María Mercedes
dc.date.accessioned2024-01-15T12:32:02Z
dc.date.available2024-01-15T12:32:02Z
dc.date.issued2019
dc.descriptionPlant proteases play a crucial role in many different biological processes along the plant life cycle. One of the most determinant stages in which proteases are key protagonists is the plant germination through the hydrolysis and mobilization of other proteins accumulated in seeds and cereal grains. The most represented proteases in charge of this are the cysteine proteases group, including the C1A family known as papain-like and the C13 family also called legumains. In cereal species such as wheat, oat or rye, gluten is a very complex mixture of grain storage proteins, which may affect the health of sensitive consumers like celiac patients. Since gluten proteins are suitable targets for plant proteases, the knowledge of the proteases involved in storage protein mobilization could be employed to manipulate the amount of gluten in the grain. Some proteases have been previously found to exhibit promising properties for their application in the degradation of known toxic peptides from gluten. To explore the variability in gluten-degrading capacities, we have now analyzed the degradation of gluten from different wheat cultivars using several cysteine proteases from barley. The wide variability showed highlights the possibility to select the protease with the highest potential to alter grain composition reducing the gluten content. Consequently, new avenues could be explored combining genetic manipulation of proteolytic processes with silencing techniques to be used as biotechnological tools against gluten-related disorders.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.statuspub
dc.identifier.citationMartinez, Manuel, et al. «Plant Proteases: From Key Enzymes in Germination to Allies for Fighting Human Gluten-Related Disorders». Frontiers in Plant Science, vol. 10, mayo de 2019, p. 721. https://doi.org/10.3389/fpls.2019.00721.
dc.identifier.doi10.3389/fpls.2019.00721
dc.identifier.essn1662-453X
dc.identifier.issn1662-4548
dc.identifier.officialurlhttps://doi.org/10.3389/fpls.2019.00721
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93083
dc.issue.number721
dc.journal.titleFrontiers in Plant Science
dc.language.isoeng
dc.page.final8
dc.page.initial1
dc.publisherFrontiers
dc.relation.projectID(projectBIO2014-53508-R andAGL2016-80566-P)
dc.rights.accessRightsopen access
dc.subject.cdu581.19
dc.subject.cdu581.15
dc.subject.cdu616.34-008.6
dc.subject.keywordCysteineprotease
dc.subject.keywordGermination
dc.subject.keywordProteolysis
dc.subject.keywordGluten
dc.subject.keywordCeliac disorders
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmFisiología vegetal (Biología)
dc.subject.ucmGenética
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2417 Biología Vegetal (Botánica)
dc.subject.unesco2409 Genética
dc.titlePlant Proteases: From Key Enzymes in Germination to Allies for Fighting Human Gluten-Related Disorders
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublicationecb86508-86f5-4719-beed-e6870a1a8732
relation.isAuthorOfPublication.latestForDiscoveryecb86508-86f5-4719-beed-e6870a1a8732

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