Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery
| dc.contributor.author | Gisbert Garzarán, Miguel | |
| dc.contributor.author | Lozano Borregón, Daniel | |
| dc.contributor.author | Vallet Regí, María Dulce Nombre | |
| dc.contributor.author | Manzano García, Miguel | |
| dc.date.accessioned | 2023-06-17T21:49:18Z | |
| dc.date.available | 2023-06-17T21:49:18Z | |
| dc.date.issued | 2016-12-07 | |
| dc.description | RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) | |
| dc.description.abstract | A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment. | |
| dc.description.department | Depto. de Química en Ciencias Farmacéuticas | |
| dc.description.faculty | Fac. de Farmacia | |
| dc.description.refereed | TRUE | |
| dc.description.sponsorship | Unión Europea. H2020 | |
| dc.description.sponsorship | European Research Council | |
| dc.description.sponsorship | Ministerio de Economía y Competitividad (MINECO) | |
| dc.description.status | inpress | |
| dc.eprint.id | https://eprints.ucm.es/id/eprint/40875 | |
| dc.identifier.doi | 10.1039/C6RA26771H | |
| dc.identifier.issn | 2046-2069 | |
| dc.identifier.officialurl | http://www.rsc.org/ | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14352/17591 | |
| dc.journal.title | RSC Advances | |
| dc.language.iso | eng | |
| dc.publisher | Royal Society of Chemistry | |
| dc.relation.projectID | MOZART (685872) | |
| dc.relation.projectID | VERDI (694160) | |
| dc.rights | Atribución 3.0 España | |
| dc.rights.accessRights | open access | |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/es/ | |
| dc.subject.cdu | 66 | |
| dc.subject.cdu | 546 | |
| dc.subject.cdu | 615.46 | |
| dc.subject.keyword | Biomaterials | |
| dc.subject.keyword | Polymers | |
| dc.subject.keyword | Materiales biomédicos | |
| dc.subject.keyword | Polímeros | |
| dc.subject.ucm | Materiales | |
| dc.subject.ucm | Química inorgánica (Química) | |
| dc.subject.unesco | 3312 Tecnología de Materiales | |
| dc.subject.unesco | 2303 Química Inorgánica | |
| dc.title | Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery | |
| dc.type | journal article | |
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