Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery

Simple item page
dc.contributor.authorGisbert Garzarán, Miguel
dc.contributor.authorLozano Borregón, Daniel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorManzano García, Miguel
dc.date.accessioned2023-06-17T21:49:18Z
dc.date.available2023-06-17T21:49:18Z
dc.date.issued2016-12-07
dc.descriptionRESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractA novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. H2020
dc.description.sponsorshipEuropean Research Council
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/40875
dc.identifier.citation1 O. C. Farokhzad and R. Langer, ACS Nano, 2009, 3, 16–20. 2 J. D. Byrne, T. Betancourt and L. Brannon-Peppas, Adv. Drug Deliv. Rev., 2008, 60, 1615–1626. 3 S. Mura, J. Nicolas and P. Couvreur, Nat. Mater., 2013, 12, 991–1003. 4 R. Misra, S. Acharya and S. K. Sahoo, Drug Discov. Today, 2010, 15, 842–850. 5 A. Baeza, M. Manzano, M. Colilla and M. Vallet-regí, Biomater. Sci., 2016, 4, 803–813. 6 F. Tang, L. Li and D. Chen, Adv. Mater., 2012, 24, 1504–1534. 7 Z. Li, J. C. Barnes, A. Bosoy, J. F. Stoddart and J. I. Zink, Chem. Soc. Rev., 2012, 41, 2590. 8 C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. a Brown, T. N. Hanna, J. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody and C. J. Brinker, Nat. Mater., 2011, 10, 389–397. 9 I. I. Slowing, J. L. Vivero-Escoto, B. G. Trewyn and V. S.-Y. Lin, J. Mater. Chem., 2010, 20, 7924–7937. 10 M. Manzano and M. Vallet-Regí, J. Mater. Chem., 2010, 20, 5593. 11 B. G. Trewyn, I. I. Slowing, S. Giri, H. Chen and V. S. Lin, Acc. Chem. Res., 2007, 40, 846–853. 12 J. L. Vivero-Escoto, I. I. Slowing, B. G. Trewyn and V. S.-Y. Lin, Small, 2010, 6, 1952–1967. 13 C. Argyo, V. Weiss, C. Bräuchle and T. Bein, Chem. Mater., 2014, 26, 435– 451. 14 Y. Zhang, Z. Zhi, T. Jiang, J. Zhang, Z. Wang and S. Wang, J. Control. Release, 2010, 145, 257–263. 15 A. Baeza, M. Colilla and M. Vallet-Regí, Expert Opin. Drug Deliv., 2015, 12, 319–337. 16 T. Kolter and K. Sandhoff, FEBS Lett., 2010, 584, 1700–1712. 17 Z. Li, H. Li, L. Liu, X. You, C. Zhang and Y. Wang, RSC Adv., 2015, 5, 77097– 77105. 18 Y. Yan, J. Fu, X. Liu, T. Wang and X. Lu, RSC Adv., 2015, 5, 30640–30646. 19 A. Sagi, R. Weinstain, N. Karton and D. Shabat, J. Am. Chem. Soc., 2008, 8, 5434–5435. 20 W. Wang and C. Alexander, Angew. Chemie - Int. Ed., 2008, 47, 7804–7806. 21 S. Gnaim and D. Shabat, Acc. Chem. Res., 2014, 47, 2970–2984. 22 R. A. McBride and E. R. Gillies, Macromolecules, 2013, 46, 5157–5166. 23 A. Baeza, E. Guisasola, A. Torres-Pardo, J. M. González-Calbet, G. J. Melen, M. Ramirez and M. Vallet-Regí, Adv. Funct. Mater., 2014, 24, 4625–4633. 24 A. S. Timin, A. R. Muslimov, K. V. Lepik, N. N. Saprykina, V. S. Sergeev, B. V. Afanasyev, A. D. Vilesov and G. B. Sukhorukov, J. Mater. Chem. B, 2016, 18, 33–37. 25 A. S. Timin, H. Gao, D. V. Voronin, D. A. Gorin and G. B. Sukhorukov, Adv. Mater. Interfaces, 2016. 26 B. Gonzalez, M. Colilla, C. L. de Laorden and M. Vallet-Regi, J. Mater. Chem., 2009, 19, 9012–9024. 27 A. Verma and F. Stellacci, Small, 2010, 6, 12–21. 28 K. Ulbrich, K. Holá, V. Šubr, A. Bakandritsos, J. Tuček and R. Zbořil, Chem. Rev., 2016, 116, 5338–5431.
dc.identifier.doi10.1039/C6RA26771H
dc.identifier.issn2046-2069
dc.identifier.officialurlhttp://www.rsc.org/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/17591
dc.journal.titleRSC Advances
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.projectIDMOZART (685872)
dc.relation.projectIDVERDI (694160)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu66
dc.subject.cdu546
dc.subject.cdu615.46
dc.subject.keywordBiomaterials
dc.subject.keywordPolymers
dc.subject.keywordMateriales biomédicos
dc.subject.keywordPolímeros
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Química)
dc.subject.unesco3312 Tecnología de Materiales
dc.subject.unesco2303 Química Inorgánica
dc.titleSelf-Immolative Polymers as novel pH-responsive gate keepers for drug delivery
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication0d246121-187b-405e-91ad-48275cebf577
relation.isAuthorOfPublicationbf1fb240-43ed-4474-8dc0-2491074f4ad3
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication2a7febe9-6dd2-4117-aa12-552e54c12bd3
relation.isAuthorOfPublication.latestForDiscovery0d246121-187b-405e-91ad-48275cebf577
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
05_201701_MG_RSCAD_Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery.pdf
Size:
1.29 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos