Immunocytochemical study on the triple origin of the sphincter iris in the chick embryo

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dc.contributor.authorBarrio Asensio, María Del Carmen
dc.contributor.authorMurillo González, Jorge Alfonso
dc.contributor.authorPeña Melián, Ángel
dc.contributor.authorPuerta Fonollá, Javier
dc.date.accessioned2023-06-20T20:16:53Z
dc.date.available2023-06-20T20:16:53Z
dc.date.copyrightReceived: 17 March 1999 / Accepted: 17 May 1999
dc.date.issued1999-10
dc.description.abstractThe ontogenic development of the sphincter iris has been studied by immunocytochemistry and standard staining on chick embryos from stage 25 HH to the time of hatching. We have used the monoclonal antibody 13F4, a highly specific marker of muscular cells. We have observed three different regions in the iris. Tn the pupillary region, immunoreactive cells are in continuous contact with the inner epithelium of the pupillary margin. In the intermediate region, the outer epithelium forms buds of pigmented cells that emigrate toward the stroma. In this epithelium cells that are totally or partially unpigmented exist, and they are 13F4 positive. In the sphincter we have observed 13F4 positive cells with melanin granules. In the ciliary region, the immunoreactivity appears in dispersed mesenchymal cells. The present findings are consistent with a triple origin of the sphincter iris in the chick embryo. This muscle is derived from the inner epithelium of the pupillary margin, the intermediate region of the outer epithelium, and from the mesenchymal cells. The cells of the inner epithelium of the pupillary margin are differentiated into smooth muscle cells, and the remaining cells form striated muscle cells.en
dc.description.departmentDepto. de Anatomía y Embriología
dc.description.departmentUnidad Docente de Anatomía y Embriología
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/38523
dc.identifier.citationBarrio Asensio, M. C., Murillo González, J. A., Peña Melián, Á., Puerta Fonollá, J. «Immunocytochemical Study on the Triple Origin of the Sphincter Iris in the Chick Embryo». Development Genes and Evolution, vol. 209, n.o 10, octubre de 1999, pp. 620-24. Springer Link, https://doi.org/10.1007/s004270050296.
dc.identifier.doi10.1007/s004270050296
dc.identifier.issn0949-944X
dc.identifier.officialurlhttp://dx.doi.org/10.1007/s004270050296
dc.identifier.relatedurlhttp://link.springer.com/article/10.1007/s004270050296
dc.identifier.urihttps://hdl.handle.net/20.500.14352/60010
dc.issue.number10
dc.journal.titleDevelopment Genes and Evolution
dc.language.isoeng
dc.page.final624
dc.page.initial620
dc.publisherSpringer-Verlag
dc.rights.accessRightsrestricted access
dc.subject.cdu617.721
dc.subject.cdu611.842
dc.subject.keywordsphincter iris
dc.subject.keywordchick embryo
dc.subject.keywordiris development
dc.subject.keywordmonoclonal antibody 13F4
dc.subject.ucmAnatomía
dc.subject.ucmOftalmología
dc.subject.unesco2410.02 Anatomía Humana
dc.subject.unesco3201.09 Oftalmología
dc.titleImmunocytochemical study on the triple origin of the sphincter iris in the chick embryo
dc.typejournal article
dc.volume.number209
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery7a351e41-71e3-4b0e-b130-49213b6b3d50
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