Impact of selection for birth weight variability on reproductive longevity: A mice model

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dc.contributor.authorFormoso Rafferty, Nora
dc.contributor.authorGutiérrez García, Juan Pablo
dc.contributor.authorGarcía Álvarez, Andrés
dc.contributor.authorPérez Pérez, Teresa
dc.contributor.authorCervantes Navarro, Isabel
dc.date.accessioned2023-06-22T10:47:00Z
dc.date.available2023-06-22T10:47:00Z
dc.date.issued2022-03-19
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractUniformity, understood as a similar performance in relevant livestock traits, such as birth weight within the litter, is being included as one of the selection objectives in breeding programmes, especially for polytocous livestock species. A divergent selection experiment for birth weight within-litter variability in mice during 23 generations showed that homogeneous animals were better for litter size, survival and feed efficiency but less heavy than heterogeneous animals. The aim of this study was to compare the reproductive longevity in both divergent lines as time to the end of the reproductive period. Two generations from both lines with an initial number of 43 females and 43 males were mated one to one and stayed together to have consecutive parturitions until the end of the reproductive life. Females were discarded when the time elapsed from the last parturition was longer than 63 days. The time to the end of the reproductive period between both lines was compared by fitting a Cox proportional hazard regression model adjusting for line, generation and its interaction. The rate of parturitions in both lines was also compared using a Prentice–Williams–Peterson model adjusted for the same effects. The low variability line was associated with a higher parturition rate, e.g., adjusted hazard ratio was 2.93 (95% CI 2.17–3.94). The Cox model showed that the low variability females also presented benefits of time to the end of the reproductive period, with an adjusted hazard ratio of 0.26 (95% CI 0.16–0.41). The median of reproductive days was 55.50 in the high variability line whilst the median was 252.50 daysforthe low variability females. The homogeneous line presented important reproductive advantages suggesting higher robustness and animal welfare. Further research should confirm whether the findings presented here of a better performance in the low variability line could be properly applied to some livestock species.
dc.description.departmentDepto. de Estadística y Ciencia de los Datos
dc.description.departmentDepto. de Producción Animal
dc.description.facultyFac. de Estudios Estadísticos
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/72908
dc.identifier.doi10.1111/jbg.12676
dc.identifier.issn0931-2668
dc.identifier.officialurlhttps://doi.org/10.1111/jbg.12676
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71656
dc.issue.number4
dc.journal.titleJournal of Animal Breeding and Genetics
dc.language.isoeng
dc.page.final379
dc.page.initial370
dc.publisherWiley
dc.relation.projectIDPGC2018-096198-A-I00
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.keyworddivergent selection
dc.subject.keywordlongevity
dc.subject.keywordmouse
dc.subject.keywordrobustness
dc.subject.keyworduniformity
dc.subject.ucmVeterinaria
dc.subject.ucmProducción animal
dc.subject.unesco3109 Ciencias Veterinarias
dc.subject.unesco3104 Producción Animal
dc.titleImpact of selection for birth weight variability on reproductive longevity: A mice model
dc.typejournal article
dc.volume.number139
dspace.entity.typePublication
relation.isAuthorOfPublication775a101d-d1b4-41be-99ec-f8a430157e08
relation.isAuthorOfPublication658d1598-6b44-4b66-b2e5-52b3dcf7f040
relation.isAuthorOfPublication2af4bfbb-c015-4552-94b1-ad7dea72ad6e
relation.isAuthorOfPublication.latestForDiscovery775a101d-d1b4-41be-99ec-f8a430157e08
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