New antibiotics against DNA. Topoisomerase I of S. pneumoniae

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dc.conference.date29 de septiembre-01 de octubre de 2010
dc.conference.placePamplona
dc.conference.title5th International Meeting on Biotechnology
dc.contributor.authorGarcía Esteban, María Teresa
dc.contributor.authorBlázquez Ferrer, María Amparo
dc.contributor.authorFerrandiz Avellano, María josé
dc.contributor.authorSanz Ferrando, María Jesús
dc.contributor.authorSilva Martín, Noella
dc.contributor.authorHermoso Domínguez, Juan Antonio
dc.date.accessioned2026-01-19T13:38:15Z
dc.date.available2026-01-19T13:38:15Z
dc.date.issued2010-01
dc.description.abstractS. pneumoniae is the main ethological agent of community-acquired pneumonia. Pneumococcal DNA topoisomerase complement, that control its DNA topology, consists of two type II enzymes (DNA gyrase and DNA topoisomerase IV) and a single type I enzyme (DNA topoisomerase I, TopA). While fluoroquinolone antibiotics target the type II topoisomerases, no antibiotics against TopA has yet been reported. Antibiotic resistance is a serious clinical problem in all the world. An increase in resistance to fluoroquinolones in S. pneumoniae it is not unexpected. Therefore, it is necessary to look for new antibiotics against new targets
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.statusunpub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/130565
dc.language.isospa
dc.rights.accessRightsrestricted access
dc.subject.cdu579.862.1
dc.subject.cdu577.21
dc.subject.cdu615.33
dc.subject.cdu577.15
dc.subject.cdu616.24-002
dc.subject.cdu615.015.8
dc.subject.ucmMicrobiología médica
dc.subject.ucmBiología molecular (Biología)
dc.subject.ucmFarmacología (Medicina)
dc.subject.unesco3201.03 Microbiología Clínica
dc.subject.unesco2302.21 Biología Molecular
dc.subject.unesco2302.22 Farmacología Molecular
dc.titleNew antibiotics against DNA. Topoisomerase I of S. pneumoniae
dc.typeconference poster
dc.type.hasVersionAM
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoverybda3e5ed-dc29-4a85-95f4-444b6119db30

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