The lord of the Lungs: the essential role of pulmonary surfactant upon inhalation of nanoparticles

Simple item page
dc.contributor.authorGarcía-Mouton, Cristina
dc.contributor.authorHidalgo Román, Alberto
dc.contributor.authorCruz Rodríguez, Antonio
dc.contributor.authorPérez-Gil, Jesús
dc.date.accessioned2023-06-17T13:31:42Z
dc.date.available2023-06-17T13:31:42Z
dc.date.issued2019-09-24
dc.description.abstractThe rapid development of nanotechnology is opening a huge world of promising possibilities in healthcare, but this is also increasing the necessity to study the potential risk of nanoparticles on public health and the environment. Since the main route for airborne particles to enter into our organism is through the lungs, it has become essential to prove that the nanoparticles generated by human activities do not compromise the respiratory function. This review explains the key role of pulmonary surfactant to sustain the normal function of breathing, as well as the stability and immunity of lungs. Particular emphasis is made on the importance of analysing the features of nanoparticles, defining their interactions with surfactant and unravelling the mutual effects. The implication of the nanoparticle-surfactant interaction on the function and fate of both structures is described, as well as the main in vitro methodologies used to evaluate this interaction. Finally, the incorporation of pulmonary surfactant in appropriate in vitro models is used in order to obtain an extensive understanding of how nanoparticles may act in the context of the lung. The main goal of this review is to offer a general view on inhaled nanoparticles and their effects on the structure and function of lungs derived from their interaction with the pulmonary surfactant system.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Biológicas)
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/57396
dc.identifier.doi10.1016/j.ejpb.2019.09.020
dc.identifier.issn0939-6411, ESSN: 1873-3441
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0939641119308690
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13689
dc.journal.titleEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.language.isoeng
dc.page.final243
dc.page.initial230
dc.publisherElsevier
dc.relation.projectID(RTI2018-094564-B-I00)
dc.relation.projectIDNANOBIOCARGO-CM (P2018/NMT-4389)
dc.rights.accessRightsrestricted access
dc.subject.cdu577.112
dc.subject.cdu577.21
dc.subject.keywordLung inhalation
dc.subject.keywordAirborne particles
dc.subject.keywordDrug delivery
dc.subject.keywordIn vitro air-blood barrier
dc.subject.ucmBiología molecular (Biología)
dc.subject.ucmBioquímica (Biología)
dc.subject.unesco2415 Biología Molecular
dc.subject.unesco2302 Bioquímica
dc.titleThe lord of the Lungs: the essential role of pulmonary surfactant upon inhalation of nanoparticles
dc.typejournal article
dc.volume.number144
dspace.entity.typePublication
relation.isAuthorOfPublicationcbc9b09a-1d4a-42e5-95c0-efb191f5d480
relation.isAuthorOfPublication.latestForDiscoverycbc9b09a-1d4a-42e5-95c0-efb191f5d480
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
García Mouton, C. et al. 2019. The lord of the lungs....pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos