Higher prevalence of LAP+ (Latency TGFβ-Associated Peptide) T cells at the tissue level in patients with early gastric cancer

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dc.contributor.authorAguinaga Barrilero, Ana
dc.contributor.authorJuárez Martín-Delgado, Ignacio
dc.contributor.authorVaquero Yuste, Christian
dc.contributor.authorMolina Alejandre, Marta
dc.contributor.authorGutiérrez Calvo, Alberto
dc.contributor.authorLasa, Inmaculada
dc.contributor.authorLópez, Adela
dc.contributor.authorGómez, Remedios
dc.contributor.authorMolanes López, Elisa María
dc.contributor.authorMartín Villa, José Manuel
dc.date.accessioned2023-06-22T12:27:44Z
dc.date.available2023-06-22T12:27:44Z
dc.date.issued2022-10-28
dc.description.abstractThe presence of cells with regulatory functions in patients with cancer is one of the mechanisms whereby the immune system cannot confront tumor growth. We sought to determine the prevalence of immunoregulatory Tcell subpopulations, expressing the latency TGFβ-associated peptide (LAP), in patients with gastric adenocarcinoma. T cells were enriched from blood or gastric tissue (tumoral, TT or tumor-free, TF) samples from 22 patients, 6 with early (EGC) and 16 with advanced gastric cancer (AGC). CD4, CD8, LAP, FoxP3 and IFN-γ were measured by cytometry. CD8 + LAP + cells were increased at tumoral sites, especially in early stages of the disease, as compared to tumor-free explants (EGC 5.28 % [4.67–6.64]*; AGC 2.90 % [1.37–4.44]; TF 3.14 % [2.33–4.16]; *p < 0.05 vs TF). Likewise, the LAP+/CD8 + LAP- ratio is increased in gastric samples from patients with early disease (EGC 0.38 [0.30–0.45]*, AGC 0.12 [0.07–0.14]; TF 0.12 [0.09–0.31]; *p < 0.05 vs AGC). Disease progression is accompanied by decreased LAP membrane expression and, probably, increased LAP secretion, therefore limiting the response to the tumor.en
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipUniversidad Complutense de Madrid—Real Colegio Complutense Harvard. Ayuda contratos predoctorales CT18/16
dc.description.sponsorshipCrue Universidades Españolas-Consejo Superior de Investigaciones Científicas (Acuerdos Transformativos 2022)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/75327
dc.identifier.citationAguinaga-Barrilero A, Juarez I, Vaquero-Yuste C, Molina-Alejandre M, Gutiérrez-Calvo A, Lasa I, López A, Gómez R, Molanes-López EM, Martin-Villa JM. Higher prevalence of LAP+ (Latency TGFβ-Associated Peptide) T cells at the tissue level in patients with early gastric cancer. Cell Immunol. 2022 Dec;382:104635. doi: 10.1016/j.cellimm.2022.104635
dc.identifier.doi10.1016/j.cellimm.2022.104635
dc.identifier.issn1090-2163
dc.identifier.officialurlhttps://doi.org/10.1016/j.cellimm.2022.104635
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0008874922001605?via%3Dihub
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/36332356/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72560
dc.journal.titleCellular Immunology
dc.language.isoeng
dc.page.initial104635
dc.publisherElsevier
dc.relation.projectID(PS09/02096, PI18/00626 and PI18/00721)
dc.relation.projectIDPrograma Investigo - CT36/22-65-UCMINV
dc.relation.projectIDCT18/16
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu612.017
dc.subject.keywordFoxP3
dc.subject.keywordGastric adenocarcinoma
dc.subject.keywordLAP
dc.subject.keywordTGFβ
dc.subject.keywordTreg
dc.subject.ucmGastroenterología y hepatología
dc.subject.ucmInmunología
dc.subject.ucmOncología
dc.subject.unesco3205.03 Gastroenterología
dc.subject.unesco2412 Inmunología
dc.subject.unesco3201.01 Oncología
dc.titleHigher prevalence of LAP+ (Latency TGFβ-Associated Peptide) T cells at the tissue level in patients with early gastric canceren
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number382
dspace.entity.typePublication
relation.isAuthorOfPublication0894d58b-fe71-42aa-ad0a-19305823daa1
relation.isAuthorOfPublication29ce7a95-21d0-40ec-9fbe-c1062ff6d0a2
relation.isAuthorOfPublicationd6c35711-8ed5-412f-8345-8b8e3869353a
relation.isAuthorOfPublication.latestForDiscovery0894d58b-fe71-42aa-ad0a-19305823daa1
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