Estudio comparativo de lipomas atípicos/liposarcomas bien diferenciados. Evaluación diagnóstica y terapéutica
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2024
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08/11/2023
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Universidad Complutense de Madrid
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Abstract
La sospecha diagnóstica de un liposarcoma de alto grado en un contexto profesional adecuado es relativamente sencilla. Sin embargo, distinguir entre un lipoma profundo a la fascia (LPF) y un liposarcoma bien diferenciado/tumor lipomatoso atípico (LSBD/TLA) es más difícil. Clínicamente, los LPF y los LSBD/TLA son difícilmente distinguibles. En Resonancia Magnética (RM) ambas lesiones se caracterizan por un patrón adiposo similar a la grasa subcutánea, habiéndose sugerido que la presencia de septos gruesos o nodulares y la captación de contraste son más frecuentes en los LSBD/TLA. La controversia continúa en la justificación de la realización o no de una biopsia antes del tratamiento y en los márgenes de resección de este...
The diagnosis of a suspected high-grade liposarcoma in an appropriate professional context is relatively straightforward. However, distinguishing between a deep-seated lipoma (DSL) and a well-differentiated liposarcoma/atypical lipomatous tumour (WDLS/ALT) is more difficult. Clinically, DSLs and WDLS/ALTs are difficult to distinguish. In Magnetic Resonance Imaging (MRI) both lesions are characterised by an adipose pattern similar to subcutaneous fat, and it has been suggested that the presence of thick or nodular septa and contrast uptake are more frequent in WDLS/ALTs. Controversy continues regarding the justification for performing or not performing a biopsy before treatment, and on the resection margins of this biopsy...
The diagnosis of a suspected high-grade liposarcoma in an appropriate professional context is relatively straightforward. However, distinguishing between a deep-seated lipoma (DSL) and a well-differentiated liposarcoma/atypical lipomatous tumour (WDLS/ALT) is more difficult. Clinically, DSLs and WDLS/ALTs are difficult to distinguish. In Magnetic Resonance Imaging (MRI) both lesions are characterised by an adipose pattern similar to subcutaneous fat, and it has been suggested that the presence of thick or nodular septa and contrast uptake are more frequent in WDLS/ALTs. Controversy continues regarding the justification for performing or not performing a biopsy before treatment, and on the resection margins of this biopsy...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 08-11-2023