Oral bioaccessibility and probabilistic human health risk assessment of potentially toxic elements in stream sediments from an abandoned gold mine in Panama

Abstract

In this study, the oral bioaccessibility of potentially toxic elements (PTEs) (As, Ba, Cu, Sb, and Zn) in river sediments from the abandoned Remance Mine was evaluated, and the associated human health risks from exposure to these contaminants through accidental ingestion during recreational activities were assessed using a probabilistic approach. The pseudo-total concentrations and bioaccessible fractions (BAF) of the selected PTEs were determined using the Unified BARGE Method (UBM), which simulates the human digestive process for both the gastric (G-phase) and gastrointestinal (GI-phase) phases. The results indicate that the BAF of PTEs was higher in the G-phase than in the GI-phase. In the G-phase, the BAF followed this decreasing order: Cu > Ba > Zn > As > Sb, while in the GI-phase, the order was Cu > Zn > Ba > As > Sb. Regarding the risk assessment, As emerged as the most significant contaminant, exceeding the safe exposure limits for both carcinogenic (CR) and non-carcinogenic (HQ) risk, mainly in children. The CR for the pseudo-total concentration was 10 times higher than in the G-phase and 18 times higher than in the GI-phase. The HQ results indicated values exceeding the safe exposure threshold only in the pseudo-total concentration. These findings highlight that the incorporation of bioaccessibility into risk assessments provides more accurate estimates. This is a novel study, the first one carried out in Panama, which investigates the oral bioaccessibility of potentially toxic elements (PTEs) in stream sediments from the Remance gold mine, an area with high concentrations of As, Cu, Zn, Sb, and Ba. Finally, the importance of managing river use in contaminated mining environments is underscored, and some recommendations are provided, aimed to make these sustainable.