Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives

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dc.contributor.authorAlcaide, Benito
dc.contributor.authorAlmendros, Pedro
dc.contributor.authorAlonso Gómez, José Miguel
dc.date.accessioned2023-06-20T01:02:29Z
dc.date.available2023-06-20T01:02:29Z
dc.date.issued2011-09-13
dc.description.abstractThe last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.
dc.description.departmentDepto. de Química Orgánica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICIIN)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipBanco Santander/Universidad Complutense de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/66552
dc.identifier.doi10.3390/molecules16097815
dc.identifier.issn1420-3049
dc.identifier.officialurlhttps://doi.org/10.3390/molecules16097815
dc.identifier.relatedurlhttps://www.mdpi.com/1420-3049/16/9/7815
dc.identifier.urihttps://hdl.handle.net/20.500.14352/43249
dc.issue.number9
dc.journal.titleMolecules
dc.language.isoeng
dc.page.final7843
dc.page.initial7815
dc.publisherMDPI
dc.relation.projectIDCTQ2009-09318
dc.relation.projectIDS2009/PPQ-1752
dc.relation.projectIDGR35/10-A
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordgold catalysis
dc.subject.keywordalkynols
dc.subject.keywordtotal synthesis
dc.subject.keywordnatural products
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco2306 Química Orgánica
dc.titleGold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives
dc.typejournal article
dc.volume.number16
dspace.entity.typePublication
relation.isAuthorOfPublicationd770fa51-b1e8-4963-9d05-4c3f2fcc4380
relation.isAuthorOfPublication.latestForDiscoveryd770fa51-b1e8-4963-9d05-4c3f2fcc4380
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